The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

Sylvia Hartmann; Stefan Dojcinov; Snjezana Dotlic; Sarah E. Gibson; Eric D. Hsi; Wolfram Klapper; Monika Klimkowska; Socorro Maria Rodriguez Pinilla; Julia Richter; Elena Sabattini; Thomas Tousseyn; Daphne de Jong

doi:https://doi.org/10.1007/s00428-023-03554-1

The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

Sylvia Hartmann, Stefan Dojcinov, Snjezana Dotlic, Sarah E. Gibson, Eric D. Hsi, Wolfram Klapper, Monika Klimkowska, Socorro Maria Rodriguez Pinilla, Julia Richter, Elena Sabattini, Thomas Tousseyn, Daphne de Jong

Research output: Contribution to journal › Review article › Academic › peer-review

1 Citation (Scopus)

Abstract

Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of presumed high-risk patterns. Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice.

Original language	English
Pages (from-to)	451-463
Number of pages	13
Journal	Virchows Archiv
Volume	483
Issue number	4
Early online date	2023
DOIs	https://doi.org/10.1007/s00428-023-03554-1
Publication status	Published - Oct 2023

Keywords

Diagnostic workshop
Gene expression profiling
Immune microenvironment
Nodular lymphocyte predominant Hodgkin Lymphoma
T-cell/histiocyte-rich large B-cell lymphoma

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Hartmann, S., Dojcinov, S., Dotlic, S., Gibson, S. E., Hsi, E. D., Klapper, W., Klimkowska, M., Pinilla, S. M. R., Richter, J., Sabattini, E., Tousseyn, T., & de Jong, D. (2023). The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology. Virchows Archiv, 483(4), 451-463. https://doi.org/10.1007/s00428-023-03554-1

@article{7c92aa14d02442c1abbbe301932285a0,

title = "The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology",

abstract = "Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of presumed high-risk patterns. Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice.",

keywords = "Diagnostic workshop, Gene expression profiling, Immune microenvironment, Nodular lymphocyte predominant Hodgkin Lymphoma, T-cell/histiocyte-rich large B-cell lymphoma",

author = "Sylvia Hartmann and Stefan Dojcinov and Snjezana Dotlic and Gibson, {Sarah E.} and Hsi, {Eric D.} and Wolfram Klapper and Monika Klimkowska and Pinilla, {Socorro Maria Rodriguez} and Julia Richter and Elena Sabattini and Thomas Tousseyn and {de Jong}, Daphne",

note = "Funding Information: S.H. is funded by the Deutsche Forschungsgemeinschaft (Heisenberg-Professorship, HA6145/7–1). E.S. reports funding from the Associazione Italiana Leucemie, Linfomi e Mielomi (AIL), Bologna, Italy. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = oct,

doi = "https://doi.org/10.1007/s00428-023-03554-1",

language = "English",

volume = "483",

pages = "451--463",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Verlag",

number = "4",

}

Hartmann, S, Dojcinov, S, Dotlic, S, Gibson, SE, Hsi, ED, Klapper, W, Klimkowska, M, Pinilla, SMR, Richter, J, Sabattini, E, Tousseyn, T & de Jong, D 2023, 'The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology', Virchows Archiv, vol. 483, no. 4, pp. 451-463. https://doi.org/10.1007/s00428-023-03554-1

The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology. / Hartmann, Sylvia; Dojcinov, Stefan; Dotlic, Snjezana et al.
In: Virchows Archiv, Vol. 483, No. 4, 10.2023, p. 451-463.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - The spectrum of nodular lymphocyte predominant Hodgkin lymphoma

T2 - a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

AU - Hartmann, Sylvia

AU - Dojcinov, Stefan

AU - Dotlic, Snjezana

AU - Gibson, Sarah E.

AU - Hsi, Eric D.

AU - Klapper, Wolfram

AU - Klimkowska, Monika

AU - Pinilla, Socorro Maria Rodriguez

AU - Richter, Julia

AU - Sabattini, Elena

AU - Tousseyn, Thomas

AU - de Jong, Daphne

N1 - Funding Information: S.H. is funded by the Deutsche Forschungsgemeinschaft (Heisenberg-Professorship, HA6145/7–1). E.S. reports funding from the Associazione Italiana Leucemie, Linfomi e Mielomi (AIL), Bologna, Italy. Publisher Copyright: © 2023, The Author(s).

PY - 2023/10

Y1 - 2023/10

N2 - Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of presumed high-risk patterns. Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice.

AB - Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of presumed high-risk patterns. Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice.

KW - Diagnostic workshop

KW - Gene expression profiling

KW - Immune microenvironment

KW - Nodular lymphocyte predominant Hodgkin Lymphoma

KW - T-cell/histiocyte-rich large B-cell lymphoma

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U2 - https://doi.org/10.1007/s00428-023-03554-1

DO - https://doi.org/10.1007/s00428-023-03554-1

M3 - Review article

C2 - 37530790

SN - 0945-6317

VL - 483

SP - 451

EP - 463

JO - Virchows Archiv

JF - Virchows Archiv

IS - 4

ER -

The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

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Keywords

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