Abstract
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals. HIV-1 latency is regulated at the transcriptional and at multiple post-transcriptional levels. Here, we review recent insights into the possible contribution of viral RNA processing to the persistence of HIV-1 reservoirs, and discuss the clinical implications of persistence of viral RNA species in ART-treated individuals.
| Original language | English |
|---|---|
| Article number | 1751 |
| Journal | Viruses |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Sept 2021 |
Keywords
- HIV-1 latency
- HIV-1 persistence
- HIV-1 reservoir
- RNA processing
- Splicing