@article{80b4fe5901d441f8ae469443dda99117,
title = "The state-of-the-art coronary stent with crystallized sirolimus: The MiStent technology and its clinical program",
abstract = "Drug-eluting stents (DES) have been developed over recent decades and the implantation of DES is the standard of care in contemporary percutaneous coronary intervention for patients with coronary artery disease. The MiStent sirolimus-eluting stent has several unique features; ultra-thin (64 μm) struts, a bioresorbable polymer and a controlled drug release from microcrystalline sirolimus as a reservoir embedded in the vessel wall. Results of recent clinical trials demonstrated the potential performance of this state-of-the-art DES. In the present review, we provide an overview of the development of DES, in particular the design and performance of the novel MiStent sirolimus-eluting stent from technological and clinical points of view and discuss the potentials of this new type of DES.",
keywords = "CAD, DES, MiStent, PCI, bioresorbable polymer, crystallized sirolimus, drug-eluting stent",
author = "Masafumi Ono and Kuniaki Takahashi and Chao Gao and Hideyuki Kawashima and Xinlei Wu and Hironori Hara and Rutao Wang and Wykrzykowska, {Joanna J.} and Piek, {Jan J.} and Faisal Sharif and Serruys, {Patrick W.} and William Wijns and Yoshinobu Onuma",
note = "Funding Information: H Hara reports a grant for studying overseas from Japanese Circulation Society and a grant from Fukuda Foundation for Medical Technology. JJ Piek reports personal fees and non-financial support from Philips/Volcano, outside the submitted work. PW Serruys reports personal fees from Biosensors, Micel Technologies, Sinomedical Sciences Technology, Philips/Volcano, Xeltis and HeartFlow, outside the submitted work. W Wijns reports research grant and personal fees from MicroPort. He is medical advisor to Rede Optimus Research and co-founder of Argonauts, an innovation facilitator. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2020 Future Medicine Ltd.",
year = "2021",
month = jul,
day = "1",
doi = "https://doi.org/10.2217/fca-2020-0063",
language = "English",
volume = "17",
pages = "593--607",
journal = "Future cardiology",
issn = "1479-6678",
publisher = "Future Medicine Ltd.",
number = "4",
}