The structure of bovine mitochondrial F1-ATPase: an example of rotary catalysis

A. G. Leslie; J. P. Abrahams; K. Braig; R. Lutter; R. I. Menz; G. L. Orriss; M. J. van Raaij; J. E. Walker

doi:https://doi.org/10.1042/bst0270037

The structure of bovine mitochondrial F1-ATPase: an example of rotary catalysis

A. G. Leslie, J. P. Abrahams, K. Braig, R. Lutter, R. I. Menz, G. L. Orriss, M. J. van Raaij, J. E. Walker

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Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

There is now compelling evidence in support of a rotary catalytic mechanism in F1-ATPase, and, by extension, in the intact ATP synthase. Although models have been proposed to explain how protein translocation in F0 results in rotation of the gamma-subunit relative to the alpha 3/beta 3 assembly in F1 [22], these are still speculative. It seems likely that a satisfactory explanation of this mechanism will ultimately depend on structural information on the intact ATP synthase

Original language	English
Pages (from-to)	37-42
Journal	Biochemical Society Transactions
Volume	27
Issue number	2
DOIs	https://doi.org/10.1042/bst0270037
Publication status	Published - 1999

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https://doi.org/10.1042/bst0270037

Cite this

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title = "The structure of bovine mitochondrial F1-ATPase: an example of rotary catalysis",

abstract = "There is now compelling evidence in support of a rotary catalytic mechanism in F1-ATPase, and, by extension, in the intact ATP synthase. Although models have been proposed to explain how protein translocation in F0 results in rotation of the gamma-subunit relative to the alpha 3/beta 3 assembly in F1 [22], these are still speculative. It seems likely that a satisfactory explanation of this mechanism will ultimately depend on structural information on the intact ATP synthase",

author = "Leslie, {A. G.} and Abrahams, {J. P.} and K. Braig and R. Lutter and Menz, {R. I.} and Orriss, {G. L.} and {van Raaij}, {M. J.} and Walker, {J. E.}",

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AU - Leslie, A. G.

AU - Abrahams, J. P.

AU - Braig, K.

AU - Lutter, R.

AU - Menz, R. I.

AU - Orriss, G. L.

AU - van Raaij, M. J.

AU - Walker, J. E.

PY - 1999

Y1 - 1999

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AB - There is now compelling evidence in support of a rotary catalytic mechanism in F1-ATPase, and, by extension, in the intact ATP synthase. Although models have been proposed to explain how protein translocation in F0 results in rotation of the gamma-subunit relative to the alpha 3/beta 3 assembly in F1 [22], these are still speculative. It seems likely that a satisfactory explanation of this mechanism will ultimately depend on structural information on the intact ATP synthase

U2 - https://doi.org/10.1042/bst0270037

DO - https://doi.org/10.1042/bst0270037

M3 - Article

C2 - 10093703

SN - 0300-5127

VL - 27

SP - 37

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JO - Biochemical Society Transactions

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