The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1

Julien J. Karrich, Melania Balzarolo, Heike Schmidlin, Marion Libouban, Maho Nagasawa, Rebecca Gentek, Shimeru Kamihira, Takahiro Maeda, Derk Amsen, Monika C. Wolkers, Bianca Blom

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Plasmacytoid dendritic cells (pDCs) selectively express Toll-like receptor (TLR)-7 and TLR-9, which allow them to rapidly secrete massive amounts of type I interferons after sensing nucleic acids derived from viruses or bacteria. It is not completely understood how development and function of pDCs are controlled at the transcriptional level. One of the main factors driving pDC development is the ETS factor Spi-B, but little is known about its target genes. Here we demonstrate that Spi-B is crucial for the differentiation of hematopoietic progenitor cells into pDCs by controlling survival of pDCs and its progenitors. In search for Spi-B target genes, we identified the antiapoptotic gene Bcl2-A1 as a specific and direct target gene, thereby consolidating the critical role of Spi-B in cell survival. (Blood. 2012; 119(22): 5191-5200)
Original languageEnglish
Pages (from-to)5191-5200
JournalBlood
Volume119
Issue number22
DOIs
Publication statusPublished - 2012

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