The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1

Julien J. Karrich; Melania Balzarolo; Heike Schmidlin; Marion Libouban; Maho Nagasawa; Rebecca Gentek; Shimeru Kamihira; Takahiro Maeda; Derk Amsen; Monika C. Wolkers; Bianca Blom

doi:https://doi.org/10.1182/blood-2011-07-370239

The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1

Julien J. Karrich, Melania Balzarolo, Heike Schmidlin, Marion Libouban, Maho Nagasawa, Rebecca Gentek, Shimeru Kamihira, Takahiro Maeda, Derk Amsen, Monika C. Wolkers, Bianca Blom

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Plasmacytoid dendritic cells (pDCs) selectively express Toll-like receptor (TLR)-7 and TLR-9, which allow them to rapidly secrete massive amounts of type I interferons after sensing nucleic acids derived from viruses or bacteria. It is not completely understood how development and function of pDCs are controlled at the transcriptional level. One of the main factors driving pDC development is the ETS factor Spi-B, but little is known about its target genes. Here we demonstrate that Spi-B is crucial for the differentiation of hematopoietic progenitor cells into pDCs by controlling survival of pDCs and its progenitors. In search for Spi-B target genes, we identified the antiapoptotic gene Bcl2-A1 as a specific and direct target gene, thereby consolidating the critical role of Spi-B in cell survival. (Blood. 2012; 119(22): 5191-5200)

Original language	English
Pages (from-to)	5191-5200
Journal	Blood
Volume	119
Issue number	22
DOIs	https://doi.org/10.1182/blood-2011-07-370239
Publication status	Published - 2012

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https://doi.org/10.1182/blood-2011-07-370239

Cite this

Karrich, J. J., Balzarolo, M., Schmidlin, H., Libouban, M., Nagasawa, M., Gentek, R., Kamihira, S., Maeda, T., Amsen, D., Wolkers, M. C., & Blom, B. (2012). The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. Blood, 119(22), 5191-5200. https://doi.org/10.1182/blood-2011-07-370239

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abstract = "Plasmacytoid dendritic cells (pDCs) selectively express Toll-like receptor (TLR)-7 and TLR-9, which allow them to rapidly secrete massive amounts of type I interferons after sensing nucleic acids derived from viruses or bacteria. It is not completely understood how development and function of pDCs are controlled at the transcriptional level. One of the main factors driving pDC development is the ETS factor Spi-B, but little is known about its target genes. Here we demonstrate that Spi-B is crucial for the differentiation of hematopoietic progenitor cells into pDCs by controlling survival of pDCs and its progenitors. In search for Spi-B target genes, we identified the antiapoptotic gene Bcl2-A1 as a specific and direct target gene, thereby consolidating the critical role of Spi-B in cell survival. (Blood. 2012; 119(22): 5191-5200)",

author = "Karrich, {Julien J.} and Melania Balzarolo and Heike Schmidlin and Marion Libouban and Maho Nagasawa and Rebecca Gentek and Shimeru Kamihira and Takahiro Maeda and Derk Amsen and Wolkers, {Monika C.} and Bianca Blom",

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AU - Karrich, Julien J.

AU - Balzarolo, Melania

AU - Schmidlin, Heike

AU - Libouban, Marion

AU - Nagasawa, Maho

AU - Gentek, Rebecca

AU - Kamihira, Shimeru

AU - Maeda, Takahiro

AU - Amsen, Derk

AU - Wolkers, Monika C.

AU - Blom, Bianca

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AB - Plasmacytoid dendritic cells (pDCs) selectively express Toll-like receptor (TLR)-7 and TLR-9, which allow them to rapidly secrete massive amounts of type I interferons after sensing nucleic acids derived from viruses or bacteria. It is not completely understood how development and function of pDCs are controlled at the transcriptional level. One of the main factors driving pDC development is the ETS factor Spi-B, but little is known about its target genes. Here we demonstrate that Spi-B is crucial for the differentiation of hematopoietic progenitor cells into pDCs by controlling survival of pDCs and its progenitors. In search for Spi-B target genes, we identified the antiapoptotic gene Bcl2-A1 as a specific and direct target gene, thereby consolidating the critical role of Spi-B in cell survival. (Blood. 2012; 119(22): 5191-5200)

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