The two-faced progeria gene and its implications in aging and metabolism

Iliana A. Chatzispyrou, Riekelt H. Houtkooper

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Premature aging syndromes have gained much attention, not only because of their devastating symptoms but also because they might hold a key to some of the mechanisms underlying aging. The Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in the LMNA gene, which normally produces lamins A and C through alternative splicing. Due to this mutation, HGPS patients express an incompletely processed form of lamin A called progerin. In this issue of EMBO Reports, the Tazi group demonstrates how mice expressing different LMNA isoforms present opposite phenotypes in longevity, fat storage and mitochondrial function
Original languageEnglish
Pages (from-to)470-471
JournalEMBO reports
Issue number5
Publication statusPublished - 2014

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