TY - JOUR
T1 - The two-faced progeria gene and its implications in aging and metabolism
AU - Chatzispyrou, Iliana A.
AU - Houtkooper, Riekelt H.
PY - 2014
Y1 - 2014
N2 - Premature aging syndromes have gained much attention, not only because of their devastating symptoms but also because they might hold a key to some of the mechanisms underlying aging. The Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in the LMNA gene, which normally produces lamins A and C through alternative splicing. Due to this mutation, HGPS patients express an incompletely processed form of lamin A called progerin. In this issue of EMBO Reports, the Tazi group demonstrates how mice expressing different LMNA isoforms present opposite phenotypes in longevity, fat storage and mitochondrial function
AB - Premature aging syndromes have gained much attention, not only because of their devastating symptoms but also because they might hold a key to some of the mechanisms underlying aging. The Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in the LMNA gene, which normally produces lamins A and C through alternative splicing. Due to this mutation, HGPS patients express an incompletely processed form of lamin A called progerin. In this issue of EMBO Reports, the Tazi group demonstrates how mice expressing different LMNA isoforms present opposite phenotypes in longevity, fat storage and mitochondrial function
U2 - https://doi.org/10.1002/embr.201438776
DO - https://doi.org/10.1002/embr.201438776
M3 - Editorial
C2 - 24723686
SN - 1469-221X
VL - 15
SP - 470
EP - 471
JO - EMBO reports
JF - EMBO reports
IS - 5
ER -