TY - JOUR
T1 - The use of multi-domain patient reported outcome measures for detecting clinical disease progression in multiple sclerosis
AU - van ‘t Hullenaar, C. A. A.
AU - Coerver, E.
AU - Kalkers, N. F.
AU - van Kempen, Z.
AU - Koch, M.
AU - Uitdehaag, B. M. J.
AU - Killestein, J.
AU - Strijbis, E. M. M.
N1 - Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Objective: Patient reported outcome measures (PROMs) are especially relevant in times of increased interest in telehealth but little is known about their relation to functional disability measures. Methods: We assessed 248 people with MS at baseline and at > = 5-years follow-up. We investigated cross-sectional and longitudinal correlations between changes in the Guy's Neurological disability scale (GNDS), and the physical part of the Multiple Sclerosis Impact Scale (MSIS-29) and the Expanded Disability Status Scale (EDSS), 9-hole peg test (9-HPT) and timed 25-foot walk (T25FW). Results: The strongest cross-sectional correlations were found between the GNDS and EDSS in the complete cohort (r = 0.66, p <.001, n = 248) as well as in progressive patients (r = 0.72, p <.001, n = 35), and the GNDS and T25FW in progressive MS (r = 0.64, p <.001, n = 34). Longitudinal correlations were poor except for changes on the leg domain of the GNDS in relation to T25FW changes in progressive MS (r = 0.68, p <.001, n = 26). In the majority of cases a clinically significant deterioration on the EDSS also resulted in a clinically significant worsening of the GDNS and MSIS. Conclusion: Both PROMs correlate well with physical disability outcomes, and seem suitable for detecting changes in lower limb function in progressive MS. The GNDS has a higher agreement with EDSS progression than the MSIS-physical.
AB - Objective: Patient reported outcome measures (PROMs) are especially relevant in times of increased interest in telehealth but little is known about their relation to functional disability measures. Methods: We assessed 248 people with MS at baseline and at > = 5-years follow-up. We investigated cross-sectional and longitudinal correlations between changes in the Guy's Neurological disability scale (GNDS), and the physical part of the Multiple Sclerosis Impact Scale (MSIS-29) and the Expanded Disability Status Scale (EDSS), 9-hole peg test (9-HPT) and timed 25-foot walk (T25FW). Results: The strongest cross-sectional correlations were found between the GNDS and EDSS in the complete cohort (r = 0.66, p <.001, n = 248) as well as in progressive patients (r = 0.72, p <.001, n = 35), and the GNDS and T25FW in progressive MS (r = 0.64, p <.001, n = 34). Longitudinal correlations were poor except for changes on the leg domain of the GNDS in relation to T25FW changes in progressive MS (r = 0.68, p <.001, n = 26). In the majority of cases a clinically significant deterioration on the EDSS also resulted in a clinically significant worsening of the GDNS and MSIS. Conclusion: Both PROMs correlate well with physical disability outcomes, and seem suitable for detecting changes in lower limb function in progressive MS. The GNDS has a higher agreement with EDSS progression than the MSIS-physical.
KW - Disability tests
KW - Disease progression
KW - Guy's neurological disability scale
KW - Leg function
KW - Multiple sclerosis impact scale
KW - Patient reported outcome measures
KW - Progressive multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85112769715&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.msard.2021.103165
DO - https://doi.org/10.1016/j.msard.2021.103165
M3 - Article
C2 - 34404022
SN - 2211-0348
VL - 55
JO - MULTIPLE SCLEROSIS AND RELATED DISORDERS
JF - MULTIPLE SCLEROSIS AND RELATED DISORDERS
M1 - 103165
ER -