TY - JOUR
T1 - Three-dimensional magnetic resonance coronary angiography using a new blood pool contrast agent
T2 - Initial experience
AU - Bedaux, Willemijn L.F.
AU - Hofman, Mark B.M.
AU - Wielopolski, Piotr A.
AU - De Cock, Carel C.
AU - Hoffmann, Volker
AU - Oudkerk, Matthijs
AU - De Feyter, Pim J.
AU - Van Rossum, Albert C.
PY - 2002/6/17
Y1 - 2002/6/17
N2 - Objective: The aim of this feasibility study was to assess the effect of a new blood pool contrast agent on magnetic resonance coronary angiography (MRCA) in patients suspected of having coronary artery disease. Methods: Nine patients referred for diagnostic x-ray coronary angiography in the evaluation of chest pain underwent MRCA using a thin-slab three-dimensional (3D) breath-hold segmented gradient echo technique at 1.5T before and after intravenous administration of feruglose, a new blood pool contrast agent. Results: A total of 36 coronary arteries, including 15 stenoses were evaluated. Overall agreement of visually assessed stenoses > 50% was 86%. The mean signal-to-noise ratio in the left anterior descending artery (LAD) did not change significantly after contrast administration, a relative improvement of 1.2 ± 0.4 (p = 0.1), whereas the mean contrast-to-noise ratio of blood to myocardium improved by 3 ± 2 (p = 0.01). Conclusion: A thin-slab 3D breath-hold scan combined with feruglose allows rapid localization and coverage of the proximal coronary arteries.
AB - Objective: The aim of this feasibility study was to assess the effect of a new blood pool contrast agent on magnetic resonance coronary angiography (MRCA) in patients suspected of having coronary artery disease. Methods: Nine patients referred for diagnostic x-ray coronary angiography in the evaluation of chest pain underwent MRCA using a thin-slab three-dimensional (3D) breath-hold segmented gradient echo technique at 1.5T before and after intravenous administration of feruglose, a new blood pool contrast agent. Results: A total of 36 coronary arteries, including 15 stenoses were evaluated. Overall agreement of visually assessed stenoses > 50% was 86%. The mean signal-to-noise ratio in the left anterior descending artery (LAD) did not change significantly after contrast administration, a relative improvement of 1.2 ± 0.4 (p = 0.1), whereas the mean contrast-to-noise ratio of blood to myocardium improved by 3 ± 2 (p = 0.01). Conclusion: A thin-slab 3D breath-hold scan combined with feruglose allows rapid localization and coverage of the proximal coronary arteries.
KW - Coronary angiography
KW - Coronary artery disease
KW - Intravascular contrast agent
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=0035991358&partnerID=8YFLogxK
U2 - https://doi.org/10.1081/JCMR-120003953
DO - https://doi.org/10.1081/JCMR-120003953
M3 - Article
C2 - 12074142
SN - 1097-6647
VL - 4
SP - 273
EP - 282
JO - Journal of cardiovascular magnetic resonance
JF - Journal of cardiovascular magnetic resonance
IS - 2
ER -