TY - JOUR
T1 - Tiam1 takes PARt in cell polarity
AU - Mertens, A. E E
AU - Pegtel, D. Michiel
AU - Collard, John G.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Cell polarity is an essential requirement for the proper tissue development of complex organisms. This is underscored by in vivo studies showing that loss of cell polarity contributes to the formation and progression of tumours. Evolutionary conserved multiprotein complexes, such as the Par3-Par6-aPKC or, in short, the Par polarity complex, regulate the establishment of cell polarity. The small Rho GTPases CDC42 and Rac control the activation of the Par polarity complex. Evidence now implicates the Rac activator Tiam1 as a crucial component of the Par complex in regulating neuronal (axonal) and epithelial (apical-basal) polarity. Our current knowledge places Tiam1 at the centre of a pivotal biological process, the establishment and maintenance of cell polarity, and suggests that deregulation of the Tiam1-Par complex contributes to tumourigenicity.
AB - Cell polarity is an essential requirement for the proper tissue development of complex organisms. This is underscored by in vivo studies showing that loss of cell polarity contributes to the formation and progression of tumours. Evolutionary conserved multiprotein complexes, such as the Par3-Par6-aPKC or, in short, the Par polarity complex, regulate the establishment of cell polarity. The small Rho GTPases CDC42 and Rac control the activation of the Par polarity complex. Evidence now implicates the Rac activator Tiam1 as a crucial component of the Par complex in regulating neuronal (axonal) and epithelial (apical-basal) polarity. Our current knowledge places Tiam1 at the centre of a pivotal biological process, the establishment and maintenance of cell polarity, and suggests that deregulation of the Tiam1-Par complex contributes to tumourigenicity.
UR - http://www.scopus.com/inward/record.url?scp=33744999597&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.tcb.2006.04.001
DO - https://doi.org/10.1016/j.tcb.2006.04.001
M3 - Review article
C2 - 16650994
SN - 0962-8924
VL - 16
SP - 308
EP - 316
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 6
ER -