TY - JOUR
T1 - Tissue-resident memory T cells in the urogenital tract
AU - Parga-Vidal, Loreto
AU - van Aalderen, Michiel C.
AU - Stark, Regina
AU - van Gisbergen, Klaas P. J. M.
N1 - Funding Information: L.P.V. and K.P.J.M.vG. were supported by an LSBR Fellowship (# 1629) of The Landsteiner Foundation for Blood Transfusion Research, M.C.vA. was supported by The Dutch Kidney Foundation (# 18OKG22) and R.S. was supported by a Veni Fellowship (# 016.186.116) of The Dutch Research Council. Publisher Copyright: © 2022, Springer Nature Limited.
PY - 2022/4
Y1 - 2022/4
N2 - Our understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites. These tissue-resident memory T (TRM) cells can respond promptly to an infection without the need for migration, proliferation or differentiation. This rapid and local deployment of effector functions maximizes the ability of TRM cells to eliminate pathogens. TRM cells do not circulate through peripheral tissues but instead form isolated populations in the skin, gut, liver, kidneys, the reproductive tract and other organs. This long-term retention in the periphery might allow TRM cells to fully adapt to the local conditions of their environment and mount customized responses to counter infection and tumour growth in a tissue-specific manner. In the urogenital tract, TRM cells must adapt to a unique microenvironment to confer protection against potential threats, including cancer and infection, while preventing the onset of auto-inflammatory disease. In this Review, we discuss insights into the diversification of TRM cells from other memory T cell lineages, the adaptations of TRM cells to their local environment, and their enhanced capacity to counter infection and tumour growth compared with other memory T cell populations, especially in the urogenital tract.
AB - Our understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites. These tissue-resident memory T (TRM) cells can respond promptly to an infection without the need for migration, proliferation or differentiation. This rapid and local deployment of effector functions maximizes the ability of TRM cells to eliminate pathogens. TRM cells do not circulate through peripheral tissues but instead form isolated populations in the skin, gut, liver, kidneys, the reproductive tract and other organs. This long-term retention in the periphery might allow TRM cells to fully adapt to the local conditions of their environment and mount customized responses to counter infection and tumour growth in a tissue-specific manner. In the urogenital tract, TRM cells must adapt to a unique microenvironment to confer protection against potential threats, including cancer and infection, while preventing the onset of auto-inflammatory disease. In this Review, we discuss insights into the diversification of TRM cells from other memory T cell lineages, the adaptations of TRM cells to their local environment, and their enhanced capacity to counter infection and tumour growth compared with other memory T cell populations, especially in the urogenital tract.
UR - http://www.scopus.com/inward/record.url?scp=85123480140&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41581-021-00525-0
DO - https://doi.org/10.1038/s41581-021-00525-0
M3 - Review article
C2 - 35079143
SN - 1759-5061
VL - 18
SP - 209
EP - 223
JO - Nature reviews. Nephrology
JF - Nature reviews. Nephrology
IS - 4
ER -