Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy

Karin Y. van Spaendonck-Zwarts, Anna Posafalvi, Maarten P. van den Berg, Denise Hilfiker-Kleiner, Ilse A. E. Bollen, Karen Sliwa, Mariëlle Alders, Rowida Almomani, Irene M. van Langen, Peter van der Meer, Richard J. Sinke, Jolanda van der Velden, Dirk J. van Veldhuisen, J. Peter van Tintelen, Jan D. H. Jongbloed

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Abstract

Peripartum cardiomyopathy (PPCM) can be an initial manifestation of familial dilated cardiomyopathy (DCM). We aimed to identify mutations in families that could underlie their PPCM and DCM. We collected 18 families with PPCM and DCM cases from various countries. We studied the clinical characteristics of the PPCM patients and affected relatives, and applied a targeted next-generation sequencing (NGS) approach to detect mutations in 48 genes known to be involved in inherited cardiomyopathies. We identified 4 pathogenic mutations in 4 of 18 families (22%): 3 in TTN and 1 in BAG3. In addition, we identified 6 variants of unknown clinical significance that may be pathogenic in 6 other families (33%): 4 in TTN, 1 in TNNC1, and 1 in MYH7. Measurements of passive force in single cardiomyocytes and titin isoform composition potentially support an upgrade of one of the variants of unknown clinical significance in TTN to a pathogenic mutation. Only 2 of 20 PPCM cases in these families showed the recovery of left ventricular function. Targeted NGS shows that potentially causal mutations in cardiomyopathy-related genes are common in families with both PPCM and DCM. This supports the earlier finding that PPCM can be part of familial DCM. Our cohort is particularly characterized by a high proportion of TTN mutations and a low recovery rate in PPCM cases
Original languageEnglish
Pages (from-to)2165-2173
JournalEuropean Heart journal
Volume35
Issue number32
DOIs
Publication statusPublished - 2014

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