TY - JOUR
T1 - Tocilizumab in severe COVID-19 pneumonia and concomitant cytokine release syndrome
AU - van Kraaij, Tom D. A.
AU - Mostard, R. my L. M.
AU - Ramiro, Sofia
AU - Checa, Cesar Magro
AU - van Dongen, Christel M. P.
AU - van Haren, Eric H. J.
AU - Buijs, Jacqueline
AU - Landewé, Robert B. M.
PY - 2020
Y1 - 2020
N2 - Younger patients with COVID-19 may experience an exaggerated immune response to SARS-CoV-2 infection and develop cytokine release syndrome (CRS), which may be life threatening. There is no proven antiviral therapy for COVID-19 so far, but profound immunosuppression has recently been suggested as a treatment for COVID-19-associated CRS. We present a case of life-threatening CRS caused by COVID-19 infection with a favourable response to immunosuppressive therapy with tocilizumab (TCZ). The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS.
AB - Younger patients with COVID-19 may experience an exaggerated immune response to SARS-CoV-2 infection and develop cytokine release syndrome (CRS), which may be life threatening. There is no proven antiviral therapy for COVID-19 so far, but profound immunosuppression has recently been suggested as a treatment for COVID-19-associated CRS. We present a case of life-threatening CRS caused by COVID-19 infection with a favourable response to immunosuppressive therapy with tocilizumab (TCZ). The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150247260&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/32399455
U2 - https://doi.org/10.12890/2020_001675
DO - https://doi.org/10.12890/2020_001675
M3 - Article
C2 - 32399455
SN - 2284-2594
VL - 7
JO - European journal of case reports in internal medicine
JF - European journal of case reports in internal medicine
IS - 5
ER -