Towards a durable RNAi gene therapy for HIV-AIDS

Ben Berkhout; Olivier ter Brake

doi:https://doi.org/10.1517/14712590802653619

Towards a durable RNAi gene therapy for HIV-AIDS

Ben Berkhout, Olivier ter Brake

Research output: Contribution to journal › Review article › Academic › peer-review

27 Citations (Scopus)

Abstract

Background: RNA interference (RNAi) can be employed as a potent antiviral mechanism Objective: To discuss RNAi approaches to target pathogenic human viruses causing acute or chronic infections, in particular RNAi gene therapy against HIV-1. Methods: A review of relevant literature. Results/conclusions: The future of antiviral RNAi therapeutics is very promising. RNAi was discovered only a decade ago, and although we are still in the early days, the first clinical trials are already ongoing

Original language	English
Pages (from-to)	161-170
Journal	Expert Opinion on Biological Therapy
Volume	9
Issue number	2
DOIs	https://doi.org/10.1517/14712590802653619
Publication status	Published - 2009

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https://doi.org/10.1517/14712590802653619

Cite this

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abstract = "Background: RNA interference (RNAi) can be employed as a potent antiviral mechanism Objective: To discuss RNAi approaches to target pathogenic human viruses causing acute or chronic infections, in particular RNAi gene therapy against HIV-1. Methods: A review of relevant literature. Results/conclusions: The future of antiviral RNAi therapeutics is very promising. RNAi was discovered only a decade ago, and although we are still in the early days, the first clinical trials are already ongoing",

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