TY - JOUR
T1 - Towards Personalization in the Curative Treatment of Gastric Cancer
AU - Slagter, Astrid E.
AU - Vollebergh, Marieke A.
AU - Jansen, Edwin P.M.
AU - van Sandick, Johanna W.
AU - Cats, Annemieke
AU - van Grieken, Nicole C.T.
AU - Verheij, Marcel
PY - 2020/11/30
Y1 - 2020/11/30
N2 - Gastric cancer is the fifth most common cancer worldwide and has a high mortality rate. In the last decades, treatment strategy has shifted from an exclusive surgical approach to a multidisciplinary strategy. Treatment options for patients with resectable gastric cancer as recommended by different worldwide guidelines, include perioperative chemotherapy, pre- or postoperative chemoradiotherapy and postoperative chemotherapy. Although gastric cancer is a heterogeneous disease with respect to patient-, tumor-, and molecular characteristics, the current standard of care is still according to a one-size-fits-all approach. In this review, we discuss the background of the different treatment strategies in resectable gastric cancer including the current standard, the specific role of radiotherapy, and describe the current areas of research and potential strategies for personalization of therapy.
AB - Gastric cancer is the fifth most common cancer worldwide and has a high mortality rate. In the last decades, treatment strategy has shifted from an exclusive surgical approach to a multidisciplinary strategy. Treatment options for patients with resectable gastric cancer as recommended by different worldwide guidelines, include perioperative chemotherapy, pre- or postoperative chemoradiotherapy and postoperative chemotherapy. Although gastric cancer is a heterogeneous disease with respect to patient-, tumor-, and molecular characteristics, the current standard of care is still according to a one-size-fits-all approach. In this review, we discuss the background of the different treatment strategies in resectable gastric cancer including the current standard, the specific role of radiotherapy, and describe the current areas of research and potential strategies for personalization of therapy.
KW - future perspectives
KW - gastric cancer
KW - multidisciplinary approach
KW - personalization
KW - radiation oncology
UR - http://www.scopus.com/inward/record.url?scp=85097609153&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fonc.2020.614907
DO - https://doi.org/10.3389/fonc.2020.614907
M3 - Review article
C2 - 33330111
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 614907
ER -