TY - JOUR
T1 - Tranexamic acid use in emergency medicine
AU - Al-Jeabory, Mahdi
AU - Gawel, Wladyslaw
AU - Gasecka, Aleksandra
AU - Szarpak, Lukasz
AU - Wieczorek, Wojciech
N1 - Publisher Copyright: Copyright © 2022 Via Medica
PY - 2022
Y1 - 2022
N2 - The most common cause of potentially preventable trauma deaths is hemorrhage. Therefore, it is crucial to understand the mechanisms regulating bleeding and clotting. The physiological mechanisms that control the coagulation process are called the coagulation cascade. In this study, we analyzed the medical literature for published articles on the use of TXA for bleeding. The MEDLINE electronic database was searched for. The keywords we have used were: “tranexamic acid”, “bleeding”, “hemorrhage”, “treatment”, “prevention”, “patient blood management”, “anti-fibrinolytic”, “surgery”, “surgery”, “trauma”, “injury” and “traumatic brain injury”. When managing the traumatic patient, time is of the essence and the same holds true for the TXA application. The largest study regarding the use of TXA in the emergency medicine CRASH-2 found that the administration of TXA within 3 hours following injury significantly reduces the mortality and that every 15-min delay in administering TXA results in increased bleeding and decreased survival by 10%, offering no benefit if administered after 3 hours. In summary, TXA is a safe and reliable agent which greatly increases the survival rate in traumatic patients suffering blood loss, reducing mortality while being safe.
AB - The most common cause of potentially preventable trauma deaths is hemorrhage. Therefore, it is crucial to understand the mechanisms regulating bleeding and clotting. The physiological mechanisms that control the coagulation process are called the coagulation cascade. In this study, we analyzed the medical literature for published articles on the use of TXA for bleeding. The MEDLINE electronic database was searched for. The keywords we have used were: “tranexamic acid”, “bleeding”, “hemorrhage”, “treatment”, “prevention”, “patient blood management”, “anti-fibrinolytic”, “surgery”, “surgery”, “trauma”, “injury” and “traumatic brain injury”. When managing the traumatic patient, time is of the essence and the same holds true for the TXA application. The largest study regarding the use of TXA in the emergency medicine CRASH-2 found that the administration of TXA within 3 hours following injury significantly reduces the mortality and that every 15-min delay in administering TXA results in increased bleeding and decreased survival by 10%, offering no benefit if administered after 3 hours. In summary, TXA is a safe and reliable agent which greatly increases the survival rate in traumatic patients suffering blood loss, reducing mortality while being safe.
KW - TXA
KW - bleeding
KW - emergency medicine
KW - tranexamic acid
KW - trauma
UR - http://www.scopus.com/inward/record.url?scp=85130626629&partnerID=8YFLogxK
U2 - https://doi.org/10.5603/DEMJ.a2022.0006
DO - https://doi.org/10.5603/DEMJ.a2022.0006
M3 - Review article
SN - 2451-4691
VL - 7
SP - 47
EP - 51
JO - Disaster and Emergency Medicine Journal
JF - Disaster and Emergency Medicine Journal
IS - 1
ER -