Abstract
Gastric Helicobacter pylori (HP) positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) develops during chronic antigenic stimulation with specific T-cell help. Chemotherapy that acts both on the malignant B-cells and on T-cells in the microenvironment, i.e. nucleoside analogs, might therefore be an attractive treatment. In 14 patients with gastric MALT lymphoma treated with fludarabine, alterations in T-cell subsets were studied in subsequent peripheral blood samples and in gastric biopsies. Treatment with fludarabine resulted in a steep decrease in T-cell subsets in peripheral blood samples. By contrast no decrease in T-cell populations was observed in subsequent gastric biopsy samples and a moderate increase was observed in relative infiltration with CD3 +, CD4 + and CD8 + cells. In addition an increase in density of FOXP3 + cells (i.e. Tregs) was seen (p = 0.047). These alterations in different T-cell subsets were not observed in gastric biopsy samples of patients treated with HP-eradication only.
Original language | English |
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Pages (from-to) | 2262-9 |
Number of pages | 8 |
Journal | Leukemia and Lymphoma |
Volume | 52 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2011 |
Keywords
- Administration, Oral
- Adult
- Aged
- Antineoplastic Agents
- Female
- Humans
- Journal Article
- Lymphoma, B-Cell, Marginal Zone
- Male
- Middle Aged
- Neoplasm Staging
- Research Support, Non-U.S. Gov't
- T-Lymphocyte Subsets
- Tumor Microenvironment
- Vidarabine