@article{e14e9d25bef844cc9af679a3c6de7d85,
title = "Treatment of venous thromboembolism in elderly patients in the era of direct oral anticoagulants",
abstract = "The incidence of venous thromboembolism (VTE) and VTE-related morbidity and mortality increase with advancing age. Over the past decade, substantial advances in the treatment of VTE have been achieved. Most notably, direct oral anticoagulants (DOACs) were introduced, which offer simple treatment regi- mens across a broad spectrum of patients with VTE and have become the first-choice anticoagulants in many individuals in this population. Even though elderly patients are underrepresented in clinical trials, the extrapolation of overall study results to the elderly subpopulation can be considered justified regarding acute VTE treatment and the choice of anticoagulant agent. In the elderly, DOACs are not only associated with a lower bleeding risk but they also appear to be even more efficacious than vitamin K antagonists in preventing recurrent VTE during the acute treatment period. Determining the optimal treatment duration is the most challenging aspect of VTE management in elderly patients. The risk of bleeding increases with advancing age, and several risk factors for recurrent VTE after stopping anticoagulation are also more frequent in the elderly. Clinical decision rules estimating the risk of recurrent VTE and bleeding have limited utility in elderly patients. Shared decision making considering patients' preferences and values is therefore crucial to help determine individual treatment duration in these patients.",
keywords = "Direct oral anticoagulants, Elderly, Pulmonary embolism, Treatment, Venous thromboembolism",
author = "Tobias Tritschler and Castellucci, {Lana A.} and {van Es}, Nick and Drahomir Aujesky and {Le Gal}, Gr{\'e}goire",
note = "Funding Information: TT, LAC, and GLG are members of the Can- VECTOR Network; the Network receives grant funding from the Cana- dian Institutes of Health Research (CDT-142654). TT holds an Early Post- doc. Mobility Award from the Swiss National Science Foundation (SNSF P2ZHP3_177999) and a Fellowship Award from the CanVECTOR Network. LAC is supported by the Heart & Stroke Foundation of Canada National New Investigator and Ontario Clinician Scientist Phase I award programs. GLG holds an Early Researcher Award from the Province of Ontario, a mid-career clinician scientist award from the Heart and Stroke Foundation of Ontario, and the Chair on the Diagnosis of Venous Thromboembolism, Department of Medicine, University of Ottawa, Canada. Funding Information: ACKNOWLEDGMENTS TT, LAC, and GLG are members of the Can‑ VECTOR Network; the Network receives grant funding from the Cana‑ dian Institutes of Health Research (CDT‑142654). TT holds an Early Post‑ doc. Mobility Award from the Swiss National Science Foundation (SNSF P2ZHP3_177999) and a Fellowship Award from the CanVECTOR Network. LAC is supported by the Heart & Stroke Foundation of Canada National New Investigator and Ontario Clinician Scientist Phase I award programs. GLG holds an Early Researcher Award from the Province of Ontario, a mid‑career clinician scientist award from the Heart and Stroke Foundation of Ontario, and the Chair on the Diagnosis of Venous Thromboembolism, Department of Medicine, University of Ottawa, Canada. CONFLICT OF INTEREST TT received travel and congress fees from Pfiz‑ er. Other authors declare no conflict of interest. Publisher Copyright: {\textcopyright} Copyright by the Author(s), 2020.",
year = "2020",
month = jun,
day = "25",
doi = "https://doi.org/10.20452/pamw.15225",
language = "English",
volume = "130",
pages = "529--538",
journal = "Polish Archives of Internal Medicine",
issn = "0032-3772",
publisher = "Medycyna Praktyczna",
number = "6",
}