TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

B.C.J. van der Eerden, L. Oei, P. Roschger, N. Fratzl-Zelman, J.G.J. Hoenderop, N.M. van Schoor, U. Pettersson-Kymmer, M. Schreuders-Koedam, A. G. Uitterlinden, A. Hofman, M. Suzuki, K. Klaushofer, C. Ohlsson, P.T.A.M. Lips, F. Rivadeneira, R.J.M. Bindels, J.P.T.M. van Leeuwen

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24 Citations (Scopus)

Abstract

We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and histomorphometrical analyses demonstrated reduced osteoclast activity and numbers in male Trpv4
Original languageEnglish
Pages (from-to)443-454
JournalBone
Volume57
Issue number2
DOIs
Publication statusPublished - 2013

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