TUMOR VOLUME AS PROGNOSTIC FACTOR IN CHEMORADIATION FOR ADVANCED HEAD AND NECK CANCER

Joost L. Knegjens; Michael Hauptmann; Frank A. Pameijer; Alfons J. Balm; Frank J. Hoebers; Josien A. de Bois; Johannes H. Kaanders; Carla M. van Herpen; Cornelia G. Verhoef; Oda B. Wijers; Ruud G. Wiggenraad; Jan Buter; Coen R. Rasch

doi:https://doi.org/10.1002/hed.21459

TUMOR VOLUME AS PROGNOSTIC FACTOR IN CHEMORADIATION FOR ADVANCED HEAD AND NECK CANCER

Joost L. Knegjens, Michael Hauptmann, Frank A. Pameijer, Alfons J. Balm, Frank J. Hoebers, Josien A. de Bois, Johannes H. Kaanders, Carla M. van Herpen, Cornelia G. Verhoef, Oda B. Wijers, Ruud G. Wiggenraad, Jan Buter, Coen R. Rasch

Research output: Contribution to journal › Article › Academic › peer-review

75 Citations (Scopus)

Abstract

Background. Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. Methods. Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. Results. The average primary tumor volume was 37.0 cm(3) (range, 2.1-182.7 cm(3); median, 28.7 cm(3)). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm(3) volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. Conclusion. For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 375-382, 2011

Original language	English
Pages (from-to)	375-382
Journal	Head & neck
Volume	33
Issue number	3
DOIs	https://doi.org/10.1002/hed.21459
Publication status	Published - 2011

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https://doi.org/10.1002/hed.21459

Cite this

@article{bcd0b17b19134a798338ab8f4a5581bd,

title = "TUMOR VOLUME AS PROGNOSTIC FACTOR IN CHEMORADIATION FOR ADVANCED HEAD AND NECK CANCER",

abstract = "Background. Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. Methods. Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. Results. The average primary tumor volume was 37.0 cm(3) (range, 2.1-182.7 cm(3); median, 28.7 cm(3)). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm(3) volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. Conclusion. For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 375-382, 2011",

author = "Knegjens, {Joost L.} and Michael Hauptmann and Pameijer, {Frank A.} and Balm, {Alfons J.} and Hoebers, {Frank J.} and {de Bois}, {Josien A.} and Kaanders, {Johannes H.} and {van Herpen}, {Carla M.} and Verhoef, {Cornelia G.} and Wijers, {Oda B.} and Wiggenraad, {Ruud G.} and Jan Buter and Rasch, {Coen R.}",

year = "2011",

doi = "https://doi.org/10.1002/hed.21459",

language = "English",

volume = "33",

pages = "375--382",

journal = "Head & neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - TUMOR VOLUME AS PROGNOSTIC FACTOR IN CHEMORADIATION FOR ADVANCED HEAD AND NECK CANCER

AU - Knegjens, Joost L.

AU - Hauptmann, Michael

AU - Pameijer, Frank A.

AU - Balm, Alfons J.

AU - Hoebers, Frank J.

AU - de Bois, Josien A.

AU - Kaanders, Johannes H.

AU - van Herpen, Carla M.

AU - Verhoef, Cornelia G.

AU - Wijers, Oda B.

AU - Wiggenraad, Ruud G.

AU - Buter, Jan

AU - Rasch, Coen R.

PY - 2011

Y1 - 2011

N2 - Background. Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. Methods. Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. Results. The average primary tumor volume was 37.0 cm(3) (range, 2.1-182.7 cm(3); median, 28.7 cm(3)). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm(3) volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. Conclusion. For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 375-382, 2011

AB - Background. Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. Methods. Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. Results. The average primary tumor volume was 37.0 cm(3) (range, 2.1-182.7 cm(3); median, 28.7 cm(3)). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm(3) volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. Conclusion. For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 375-382, 2011

U2 - https://doi.org/10.1002/hed.21459

DO - https://doi.org/10.1002/hed.21459

M3 - Article

C2 - 20629076

SN - 1043-3074

VL - 33

SP - 375

EP - 382

JO - Head & neck

JF - Head & neck

IS - 3

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