Two way communication between neutrophils and dendritic cells

Irene S Ludwig, Teunis B H Geijtenbeek, Yvette van Kooyk

Research output: Contribution to journalReview articleAcademicpeer-review

54 Citations (Scopus)


Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.

Original languageEnglish
Pages (from-to)408-13
Number of pages6
JournalCurrent Opinion in Pharmacology
Issue number4
Publication statusPublished - Aug 2006


  • Animals
  • Cell Adhesion Molecules/immunology
  • Cell Communication/immunology
  • Dendritic Cells/immunology
  • Humans
  • Immunity, Active
  • Immunity, Innate
  • Inflammation/immunology
  • Lectins, C-Type/immunology
  • Liver/immunology
  • Neutrophil Infiltration
  • Neutrophils/immunology
  • Receptors, Cell Surface/immunology
  • Th1 Cells/immunology
  • Th2 Cells/immunology

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