Two way communication between neutrophils and dendritic cells

Irene S Ludwig; Teunis B H Geijtenbeek; Yvette van Kooyk

doi:https://doi.org/10.1016/j.coph.2006.03.009

Two way communication between neutrophils and dendritic cells

Irene S Ludwig, Teunis B H Geijtenbeek, Yvette van Kooyk

Research output: Contribution to journal › Review article › Academic › peer-review

54 Citations (Scopus)

Abstract

Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.

Original language	English
Pages (from-to)	408-13
Number of pages	6
Journal	Current Opinion in Pharmacology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.coph.2006.03.009
Publication status	Published - Aug 2006

Keywords

Animals
Cell Adhesion Molecules/immunology
Cell Communication/immunology
Dendritic Cells/immunology
Humans
Immunity, Active
Immunity, Innate
Inflammation/immunology
Lectins, C-Type/immunology
Liver/immunology
Neutrophil Infiltration
Neutrophils/immunology
Receptors, Cell Surface/immunology
Th1 Cells/immunology
Th2 Cells/immunology

Access to Document

https://doi.org/10.1016/j.coph.2006.03.009

Cite this

@article{d89cb54ac7b44f04a50c6e65f78242e5,

title = "Two way communication between neutrophils and dendritic cells",

abstract = "Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.",

keywords = "Animals, Cell Adhesion Molecules/immunology, Cell Communication/immunology, Dendritic Cells/immunology, Humans, Immunity, Active, Immunity, Innate, Inflammation/immunology, Lectins, C-Type/immunology, Liver/immunology, Neutrophil Infiltration, Neutrophils/immunology, Receptors, Cell Surface/immunology, Th1 Cells/immunology, Th2 Cells/immunology",

author = "Ludwig, {Irene S} and Geijtenbeek, {Teunis B H} and {van Kooyk}, Yvette",

year = "2006",

month = aug,

doi = "https://doi.org/10.1016/j.coph.2006.03.009",

language = "English",

volume = "6",

pages = "408--13",

journal = "Current Opinion in Pharmacology",

issn = "1471-4892",

publisher = "Elsevier BV",

number = "4",

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TY - JOUR

T1 - Two way communication between neutrophils and dendritic cells

AU - Ludwig, Irene S

AU - Geijtenbeek, Teunis B H

AU - van Kooyk, Yvette

PY - 2006/8

Y1 - 2006/8

N2 - Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.

AB - Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.

KW - Animals

KW - Cell Adhesion Molecules/immunology

KW - Cell Communication/immunology

KW - Dendritic Cells/immunology

KW - Humans

KW - Immunity, Active

KW - Immunity, Innate

KW - Inflammation/immunology

KW - Lectins, C-Type/immunology

KW - Liver/immunology

KW - Neutrophil Infiltration

KW - Neutrophils/immunology

KW - Receptors, Cell Surface/immunology

KW - Th1 Cells/immunology

KW - Th2 Cells/immunology

U2 - https://doi.org/10.1016/j.coph.2006.03.009

DO - https://doi.org/10.1016/j.coph.2006.03.009

M3 - Review article

C2 - 16750420

SN - 1471-4892

VL - 6

SP - 408

EP - 413

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

IS - 4

ER -