Two-year efficacy and safety of Simvastatin 80 mg in familial hypercholesterolemia (The examination of probands and relatives in statin studies with familial hypercholesterolemia [ExPRESS FH])

Pernette R. W. de Sauvage Nolting, Rudolf J. A. Buirma, Barbara A. Hutten, John J. P. Kastelein

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Abstract

High-dose (80 mg) simvastatin is efficacious in both reducing low-density lipoprotein cholesterol (-48%) and triglyceride (-26%) levels and in elevating high-density lipoprotein cholesterol (+ 13%) levels in a large cohort of patients with familial hypercholesterolemia. No tachyphylaxis was seen during a 2-year treatment period, and therapy with simvastatin 80 mg was well tolerated
Original languageEnglish
Pages (from-to)181-+
JournalAmerican journal of cardiology
Volume90
Issue number2
Publication statusPublished - 2002

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