Unravelling the relation between mental illness and cardiovascular disease by triangulating evidence from different methods

Jorien L. Treur; Rada R. Veeneman; Jentien M. Vermeulen; Karin J. H. Verweij

doi:https://doi.org/10.1093/eurheartj/ehad049

Unravelling the relation between mental illness and cardiovascular disease by triangulating evidence from different methods

Jorien L. Treur, Rada R. Veeneman, Jentien M. Vermeulen, Karin J. H. Verweij

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1851-1854
Number of pages	4
Journal	European Heart journal
Volume	44
Issue number	21
DOIs	https://doi.org/10.1093/eurheartj/ehad049 https://doi.org/10.1093/eurheartj/ehad049
Publication status	Published - 1 Jun 2023

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@article{555e96222aec42c49d39ce158ce09b9d,

title = "Unravelling the relation between mental illness and cardiovascular disease by triangulating evidence from different methods",

author = "Treur, {Jorien L.} and Veeneman, {Rada R.} and Vermeulen, {Jentien M.} and Verweij, {Karin J. H.}",

note = "Funding Information: Serious mental illness, including depression, bipolar, and psychotic disorder, is among the leading causes of disability worldwide. Besides the heavy burden posed by mental/psychological distress, mental illness is also associated with comorbid cardiovascular disease (CVD). Individuals with mental illness live, on average, 10–20 years shorter than the general population and CVD is an important driver of this premature mortality. Mental illness can also arise after being diagnosed with CVD or receiving invasive CVD treatment. The mechanisms underlying these associations are poorly understood. One potential explanation is that mental illness and CVD share (genetic) risk factors. Another possibility is that there are causal effects; mental illness may causally increase the risk of developing CVD, or the reverse, CVD may causally increase the risk of mental illness. If there are causal effects, these might be mediated by other factors such as health behaviours (smoking, lack of physical activity), psychotropic medication use (which has cardio-metabolic side effects), or loneliness and social isolation. The current project, funded by a European Research Council (ERC) Starting grant (PI Jorien Treur), examines these explanations (). By bringing together innovative epidemiological and genetic methods, each with their own strengths and weaknesses, and {\textquoteleft}triangulating{\textquoteright} their findings, robust evidence can be attained. Funding Information: This project is funded by a European Research Council (ERC) Starting grant (PI Jorien Treur) with the acronym UNRAVEL-CAUSALITY and grant number 101076686.",

year = "2023",

month = jun,

day = "1",

doi = "https://doi.org/10.1093/eurheartj/ehad049",

language = "English",

volume = "44",

pages = "1851--1854",

journal = "European Heart Journal",

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publisher = "Oxford University Press",

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TY - JOUR

T1 - Unravelling the relation between mental illness and cardiovascular disease by triangulating evidence from different methods

AU - Treur, Jorien L.

AU - Veeneman, Rada R.

AU - Vermeulen, Jentien M.

AU - Verweij, Karin J. H.

N1 - Funding Information: Serious mental illness, including depression, bipolar, and psychotic disorder, is among the leading causes of disability worldwide. Besides the heavy burden posed by mental/psychological distress, mental illness is also associated with comorbid cardiovascular disease (CVD). Individuals with mental illness live, on average, 10–20 years shorter than the general population and CVD is an important driver of this premature mortality. Mental illness can also arise after being diagnosed with CVD or receiving invasive CVD treatment. The mechanisms underlying these associations are poorly understood. One potential explanation is that mental illness and CVD share (genetic) risk factors. Another possibility is that there are causal effects; mental illness may causally increase the risk of developing CVD, or the reverse, CVD may causally increase the risk of mental illness. If there are causal effects, these might be mediated by other factors such as health behaviours (smoking, lack of physical activity), psychotropic medication use (which has cardio-metabolic side effects), or loneliness and social isolation. The current project, funded by a European Research Council (ERC) Starting grant (PI Jorien Treur), examines these explanations (). By bringing together innovative epidemiological and genetic methods, each with their own strengths and weaknesses, and ‘triangulating’ their findings, robust evidence can be attained. Funding Information: This project is funded by a European Research Council (ERC) Starting grant (PI Jorien Treur) with the acronym UNRAVEL-CAUSALITY and grant number 101076686.

PY - 2023/6/1

Y1 - 2023/6/1

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U2 - https://doi.org/10.1093/eurheartj/ehad049

DO - https://doi.org/10.1093/eurheartj/ehad049

M3 - Article

C2 - 36808227

SN - 0195-668X

VL - 44

SP - 1851

EP - 1854

JO - European Heart Journal

JF - European Heart Journal

IS - 21

ER -

Unravelling the relation between mental illness and cardiovascular disease by triangulating evidence from different methods

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