Abstract
| Original language | English |
|---|---|
| Article number | e12182 |
| Journal | Journal of extracellular vesicles |
| Volume | 10 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 1 Dec 2021 |
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In: Journal of extracellular vesicles, Vol. 10, No. 14, e12182, 01.12.2021.
Research output: Contribution to journal › Editorial › Academic › peer-review
TY - JOUR
T1 - Updating MISEV
T2 - Evolving the minimal requirements for studies of extracellular vesicles
AU - Witwer, Kenneth W.
AU - Goberdhan, Deborah C. I.
AU - O'Driscoll, Lorraine
AU - Théry, Clotilde
AU - Welsh, Joshua A.
AU - Blenkiron, Cherie
AU - Buzás, Edit I.
AU - di Vizio, Dolores
AU - Erdbrügger, Uta
AU - Falcón-Pérez, Juan M.
AU - Fu, Qing-Ling
AU - Hill, Andrew F.
AU - Lenassi, Metka
AU - Lötvall, Jan
AU - Nieuwland, Rienk
AU - Ochiya, Takahiro
AU - Rome, Sophie
AU - Sahoo, Susmita
AU - Zheng, Lei
N1 - Funding Information: The authors are grateful to the ISEV community for sharing feedback on MISEV2018 and ongoing ISEV Rigor and Standardization projects. KWW: US National Institutes of Health (NIH) through AI144997, DA047807, MH118164, and CA241694, and by the Michael J. Fox Foundation (00900821); DCIG: Cancer Research UK Programme (C19591/A19076), BBSRC (BB/R004862/1); LOD: Irish Research Council Advanced Laureate Award EVIC (IRCLA/2019/49), the Depart. of Agriculture, Food and Marine (DAFM) of Ireland (17/F/234); the EU Commission H2020, funded as H2020‐MSCA‐ITN‐TRAIN‐EV (722148); and the EU Commission H2020, funded as H2020‐NMBP‐TR‐IND‐2018 EVPRO (814495); CT: INSERM; JAW: Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute, and Center for Cancer Research; EIB: VEKOP‐2.3.3‐15‐2017‐00016, H2020 SGA (739593), H2020‐MSCA‐ITN‐TRAIN‐EV (722148), Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, Therapeutic Development Thematic Program; DDV: NIH/NCI (R01 CA234557), NIH/NCI (R01 CA218526); JMF‐P: Spanish Ministry SAF2015‐66312‐R, RTI2018‐094969‐B‐I00; ML: ARRS P1‐0170, J3‐9255; SR: ANR MEXID & ANR ZENITH; SS: NIH R01HL148786, NIH R01HL140469, NIH R01DK125856. Funding Information: The authors are grateful to the ISEV community for sharing feedback on MISEV2018 and ongoing ISEV Rigor and Standardization projects. KWW: US National Institutes of Health (NIH) through AI144997, DA047807, MH118164, and CA241694, and by the Michael J. Fox Foundation (00900821); DCIG: Cancer Research UK Programme (C19591/A19076), BBSRC (BB/R004862/1); LOD: Irish Research Council Advanced Laureate Award EVIC (IRCLA/2019/49), the Depart. of Agriculture, Food and Marine (DAFM) of Ireland (17/F/234); the EU Commission H2020, funded as H2020-MSCA-ITN-TRAIN-EV (722148); and the EU Commission H2020, funded as H2020-NMBP-TR-IND-2018 EVPRO (814495); CT: INSERM; JAW: Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute, and Center for Cancer Research; EIB: VEKOP-2.3.3-15-2017-00016, H2020 SGA (739593), H2020-MSCA-ITN-TRAIN-EV (722148), Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, Therapeutic Development Thematic Program; DDV: NIH/NCI (R01 CA234557), NIH/NCI (R01 CA218526); JMF-P: Spanish Ministry SAF2015-66312-R, RTI2018-094969-B-I00; ML: ARRS P1-0170, J3-9255; SR: ANR MEXID & ANR ZENITH; SS: NIH R01HL148786, NIH R01HL140469, NIH R01DK125856. Publisher Copyright: © 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and made recommendations in the six broad topics of EV nomenclature, sample collection and pre-processing, EV separation and concentration, characterization, functional studies, and reporting requirements/exceptions. To gather opinions on MISEV and ideas for new updates, the ISEV Board of Directors canvassed previous MISEV authors and society members. Here, we share conclusions that are relevant to the ongoing evolution of the MISEV initiative and other ISEV rigour and standardization efforts.
AB - The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and made recommendations in the six broad topics of EV nomenclature, sample collection and pre-processing, EV separation and concentration, characterization, functional studies, and reporting requirements/exceptions. To gather opinions on MISEV and ideas for new updates, the ISEV Board of Directors canvassed previous MISEV authors and society members. Here, we share conclusions that are relevant to the ongoing evolution of the MISEV initiative and other ISEV rigour and standardization efforts.
UR - http://www.scopus.com/inward/record.url?scp=85121755664&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/jev2.12182
DO - https://doi.org/10.1002/jev2.12182
M3 - Editorial
C2 - 34953156
SN - 2001-3078
VL - 10
JO - Journal of extracellular vesicles
JF - Journal of extracellular vesicles
IS - 14
M1 - e12182
ER -