Urine interleukin-8 is a marker for urinary tract infection in postoperative patients

D. P. Olszyna; H. Vermeulen; A. H. Baan; P. Speelman; S. J. van Deventer; D. J. Gouma; T. van der Poll

doi:https://doi.org/10.1007/s15010-001-1157-z

Urine interleukin-8 is a marker for urinary tract infection in postoperative patients

D. P. Olszyna, H. Vermeulen, A. H. Baan, P. Speelman, S. J. van Deventer, D. J. Gouma, T. van der Poll

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Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

BACKGROUND: Urine of patients with urinary tract infection (UTI) contains high levels of interleukin (IL)-6 and IL-8. However, knowledge of the kinetics of their release in urine is limited. We therefore compared the appearance of IL-6 and IL-8 in urine after uncomplicated surgery and surgery complicated by UTI. PATIENTS AND METHODS: 165 patients undergoing abdominal surgery who received a urinary catheter were studied. Urine IL-6 and IL-8 were prospectively measured in patients who did (n = 10) or did not (n = 20) develop UTI. Statistical analysis was done by one-way ANOVA and the Mann-Whitney test. RESULTS: Although urine IL-6 increased in the 2 to 4 days preceding the bacteriological documentation of UTI, a similar increase was observed in patients who did not develop UTI. Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls. CONCLUSION: In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6

Original language	English
Pages (from-to)	274-277
Journal	Infection
Volume	29
Issue number	5
DOIs	https://doi.org/10.1007/s15010-001-1157-z
Publication status	Published - 2001

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https://doi.org/10.1007/s15010-001-1157-z

Cite this

@article{2148e416a2c24b0a87ab1b55f172bb25,

title = "Urine interleukin-8 is a marker for urinary tract infection in postoperative patients",

abstract = "BACKGROUND: Urine of patients with urinary tract infection (UTI) contains high levels of interleukin (IL)-6 and IL-8. However, knowledge of the kinetics of their release in urine is limited. We therefore compared the appearance of IL-6 and IL-8 in urine after uncomplicated surgery and surgery complicated by UTI. PATIENTS AND METHODS: 165 patients undergoing abdominal surgery who received a urinary catheter were studied. Urine IL-6 and IL-8 were prospectively measured in patients who did (n = 10) or did not (n = 20) develop UTI. Statistical analysis was done by one-way ANOVA and the Mann-Whitney test. RESULTS: Although urine IL-6 increased in the 2 to 4 days preceding the bacteriological documentation of UTI, a similar increase was observed in patients who did not develop UTI. Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls. CONCLUSION: In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6",

author = "Olszyna, {D. P.} and H. Vermeulen and Baan, {A. H.} and P. Speelman and {van Deventer}, {S. J.} and Gouma, {D. J.} and {van der Poll}, T.",

year = "2001",

doi = "https://doi.org/10.1007/s15010-001-1157-z",

language = "English",

volume = "29",

pages = "274--277",

journal = "Infection",

issn = "0300-8126",

publisher = "Urban und Vogel",

number = "5",

}

TY - JOUR

T1 - Urine interleukin-8 is a marker for urinary tract infection in postoperative patients

AU - Olszyna, D. P.

AU - Vermeulen, H.

AU - Baan, A. H.

AU - Speelman, P.

AU - van Deventer, S. J.

AU - Gouma, D. J.

AU - van der Poll, T.

PY - 2001

Y1 - 2001

N2 - BACKGROUND: Urine of patients with urinary tract infection (UTI) contains high levels of interleukin (IL)-6 and IL-8. However, knowledge of the kinetics of their release in urine is limited. We therefore compared the appearance of IL-6 and IL-8 in urine after uncomplicated surgery and surgery complicated by UTI. PATIENTS AND METHODS: 165 patients undergoing abdominal surgery who received a urinary catheter were studied. Urine IL-6 and IL-8 were prospectively measured in patients who did (n = 10) or did not (n = 20) develop UTI. Statistical analysis was done by one-way ANOVA and the Mann-Whitney test. RESULTS: Although urine IL-6 increased in the 2 to 4 days preceding the bacteriological documentation of UTI, a similar increase was observed in patients who did not develop UTI. Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls. CONCLUSION: In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6

AB - BACKGROUND: Urine of patients with urinary tract infection (UTI) contains high levels of interleukin (IL)-6 and IL-8. However, knowledge of the kinetics of their release in urine is limited. We therefore compared the appearance of IL-6 and IL-8 in urine after uncomplicated surgery and surgery complicated by UTI. PATIENTS AND METHODS: 165 patients undergoing abdominal surgery who received a urinary catheter were studied. Urine IL-6 and IL-8 were prospectively measured in patients who did (n = 10) or did not (n = 20) develop UTI. Statistical analysis was done by one-way ANOVA and the Mann-Whitney test. RESULTS: Although urine IL-6 increased in the 2 to 4 days preceding the bacteriological documentation of UTI, a similar increase was observed in patients who did not develop UTI. Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls. CONCLUSION: In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6

U2 - https://doi.org/10.1007/s15010-001-1157-z

DO - https://doi.org/10.1007/s15010-001-1157-z

M3 - Article

C2 - 11688906

SN - 0300-8126

VL - 29

SP - 274

EP - 277

JO - Infection

JF - Infection

IS - 5

ER -