TY - JOUR
T1 - Use of pulmonary inhalants remains remarkably high after atrial septal defect closure
AU - Nassif, Martina
AU - Woudstra, Odilia I.
AU - Kuijpers, Joey M.
AU - Sterk, Peter J.
AU - van Steenwijk, Reindert P.
AU - Zwinderman, Aeilko H.
AU - Bouma, Berto J.
AU - Mulder, Barbara J.
AU - de Winter, Robbert J.
PY - 2018
Y1 - 2018
N2 - Background: Post-repair atrial septal defects (ASD) patients are frequently discharged from follow-up, but the extent of pulmonary symptoms long-term post-repair is unknown. Methods and Results: The national CONgenital CORvitia registry was linked to the national Drug Registry to investigate all ambulatory-dispensed pulmonary inhalants for 2006–2014. ASD patients were compared with age-and sex-matched referents from the general population. A total of 1,959 adult patients (age 42±17 years; 66% female; 1,223 [62%] repaired) were included. Compared with the referents, ASD patients had more inhalant use, even at long-term post-repair follow-up (OR=1.81 [95% CI 1.62–2.03]; P<0.001). Conclusions: ASD patients had 2-fold higher inhalant use compared with referents even at long-term post-repair follow-up, suggesting persistent pulmonary functional impairment.
AB - Background: Post-repair atrial septal defects (ASD) patients are frequently discharged from follow-up, but the extent of pulmonary symptoms long-term post-repair is unknown. Methods and Results: The national CONgenital CORvitia registry was linked to the national Drug Registry to investigate all ambulatory-dispensed pulmonary inhalants for 2006–2014. ASD patients were compared with age-and sex-matched referents from the general population. A total of 1,959 adult patients (age 42±17 years; 66% female; 1,223 [62%] repaired) were included. Compared with the referents, ASD patients had more inhalant use, even at long-term post-repair follow-up (OR=1.81 [95% CI 1.62–2.03]; P<0.001). Conclusions: ASD patients had 2-fold higher inhalant use compared with referents even at long-term post-repair follow-up, suggesting persistent pulmonary functional impairment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055516226&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30298834
U2 - https://doi.org/10.1253/circj.CJ-18-0613
DO - https://doi.org/10.1253/circj.CJ-18-0613
M3 - Article
C2 - 30298834
SN - 1346-9843
VL - 82
SP - 2913
EP - 2916
JO - Circulation journal
JF - Circulation journal
IS - 11
ER -