TY - JOUR
T1 - Utility of Routine Esophageal Biopsies in Patients With Refractory Reflux Symptoms
AU - Oude Nijhuis, Renske A. B.
AU - Curvers, Wouter L.
AU - van der Ende, Mirjam
AU - Herregods, Thomas V. K.
AU - Schuitenmaker, Jeroen M.
AU - Smout, Andreas J. P. M.
AU - Bredenoord, Albert J.
N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/4/1
Y1 - 2021/4/1
N2 - INTRODUCTION: This study aimed to assess the diagnostic yield of routine esophageal biopsies in patients with refractory reflux symptoms. METHODS: We prospectively enrolled consecutive patients referred for upper endoscopy and collected histological, clinical, and endoscopic data. RESULTS: Of the 301 included patients, 14 (4.7%) patients met the clinicopathological diagnostic definition of eosinophilic esophagitis. Presence of dysphagia, food bolus impaction, atopic background, and typical endoscopic features were the factors with the strongest association and diagnostic accuracy for eosinophilic esophagitis. The diagnostic yield in patients lacking symptoms of dysphagia or endoscopic features was negligible (0% and 1.9%, respectively). DISCUSSION: Routine esophageal biopsy sampling in patients with refractory reflux symptoms has a low diagnostic yield. Esophageal biopsies should only be obtained in patients with refractory reflux symptoms who also present with dysphagia (see Visual abstract, Supplementary Digital Content 2, http://links.lww.com/AJG/B792).
AB - INTRODUCTION: This study aimed to assess the diagnostic yield of routine esophageal biopsies in patients with refractory reflux symptoms. METHODS: We prospectively enrolled consecutive patients referred for upper endoscopy and collected histological, clinical, and endoscopic data. RESULTS: Of the 301 included patients, 14 (4.7%) patients met the clinicopathological diagnostic definition of eosinophilic esophagitis. Presence of dysphagia, food bolus impaction, atopic background, and typical endoscopic features were the factors with the strongest association and diagnostic accuracy for eosinophilic esophagitis. The diagnostic yield in patients lacking symptoms of dysphagia or endoscopic features was negligible (0% and 1.9%, respectively). DISCUSSION: Routine esophageal biopsy sampling in patients with refractory reflux symptoms has a low diagnostic yield. Esophageal biopsies should only be obtained in patients with refractory reflux symptoms who also present with dysphagia (see Visual abstract, Supplementary Digital Content 2, http://links.lww.com/AJG/B792).
UR - http://www.scopus.com/inward/record.url?scp=85105841816&partnerID=8YFLogxK
U2 - https://doi.org/10.14309/ajg.0000000000001064
DO - https://doi.org/10.14309/ajg.0000000000001064
M3 - Article
C2 - 33982953
SN - 0002-9270
VL - 116
SP - 816
EP - 820
JO - American journal of gastroenterology
JF - American journal of gastroenterology
IS - 4
ER -