TY - JOUR
T1 - Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis
T2 - a retrospective analysis of a Dutch national cohort
AU - Boeddha, Navin P.
AU - Schlapbach, Luregn J.
AU - Visser, Idse H.
AU - Jansen, Nicolaas J. G.
AU - SKIC (Dutch Collaborative PICU Research Network)
AU - Bollen, Casper
AU - van Heerde, Marc
AU - van der Heide, Douwe
AU - Klein, Richard
AU - Kneyber, Martin
AU - Kuiper, Jan-Willem
AU - Riedijk, Maaike
AU - Verlaat, Carin
AU - van Waardenburg, Dick
N1 - Funding Information: LJS was supported by a Practitioner Fellowship of the National Health and Medical Research Council of Australia and New Zealand, and by the Children`s Hospital Foundation, Brisbane, Australia. The funders were not involved in the design of the study, collection, analysis, interpretation of data, or in writing the manuscript. Funding Information: On behalf of the SKIC (Dutch collaborative PICU Research Network), the Pediatric Intensive Care Evaluation (PICE) working group members: Casper Bollen, MD, PhD (Department of Pediatric Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands); Marc van Heerde, MD, PhD (Department of Pediatric Intensive Care, Emma Children’s Hospital, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands); Douwe van der Heide, RN (Faculty Board Member, PICE Registry, The Netherlands); Richard Klein, MD, PhD (Department of Pediatric Intensive Care, Leiden University Medical Center, Leiden, The Netherlands); Martin Kneyber, MD, PhD, FCCM (Department of Pediatric Intensive Care, University Medical Center Groningen, Groningen, The Netherlands); Jan-Willem Kuiper, MD, PhD (Department of Pediatric Intensive Care, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands); Maaike Riedijk, MD, PhD (Department of Pediatric Intensive Care, Emma Children’s Hospital, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands)); Carin Verlaat, MD (Department of Pediatric Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands); and Dick van Waardenburg, MD, PhD (Department of Pediatric Intensive Care, Academic Hospital Maastricht, Maastricht, The Netherlands). Publisher Copyright: © 2022, The Author(s).
PY - 2022/12/1
Y1 - 2022/12/1
N2 - We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n = 4096; AUC 0.70 (95% CI 0.67–0.73)) and in children with sepsis (n = 1690; AUC 0.71 (0.67–0.76)). aPSS can be an adequate tool to predict outcome in children admitted to PICU with invasive infection or sepsis, especially in situations where lactate is not available within 60 min.
AB - We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n = 4096; AUC 0.70 (95% CI 0.67–0.73)) and in children with sepsis (n = 1690; AUC 0.71 (0.67–0.76)). aPSS can be an adequate tool to predict outcome in children admitted to PICU with invasive infection or sepsis, especially in situations where lactate is not available within 60 min.
KW - Child
KW - Mortality
KW - Organ dysfunction
KW - Score
KW - Sepsis
KW - Septic shock
UR - http://www.scopus.com/inward/record.url?scp=85134061498&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s40560-022-00618-3
DO - https://doi.org/10.1186/s40560-022-00618-3
M3 - Comment/Letter to the editor
C2 - 35672773
SN - 2052-0492
VL - 10
JO - Journal of intensive care
JF - Journal of intensive care
IS - 1
M1 - 26
ER -