Validity of LIDAS (LIfetime Depression Assessment Self-report): A self-report online assessment of lifetime major depressive disorder

M. Bot, C. M. Middeldorp, E. J. C. de Geus, H. M. Lau, M. Sinke, B. van Nieuwenhuizen, J. H. Smit, D. I. Boomsma, B. W. J. H. Penninx

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)


Background There is a paucity of valid, brief instruments for the assessment of lifetime major depressive disorder (MDD) that can be used in, for example, large-scale genomics, imaging or biomarker studies on depression. We developed the LIfetime Depression Assessment Self-report (LIDAS), which assesses lifetime MDD diagnosis according to DSM criteria, and is largely based on the widely used Composite International Diagnostic Interview (CIDI). Here, we tested the feasibility and determined the sensitivity and specificity for measuring lifetime MDD with this new questionnaire, with a regular CIDI as reference. Method Sensitivity and specificity analyses of the online lifetime MDD questionnaire were performed in adults with (n = 177) and without (n = 87) lifetime MDD according to regular index CIDIs, selected from the Netherlands Study of Depression and Anxiety (NESDA) and Netherlands Twin Register (NTR). Feasibility was tested in an additional non-selective, population-based sample of NTR participants (n = 245). Results Of the 753 invited persons, 509 (68%) completed the LIDAS, of which 419 (82%) did this online. User-friendliness of the instrument was rated high. Median completion time was 6.2 min. Sensitivity and specificity for lifetime MDD were 85% [95% confidence interval (CI) 80-91%] and 80% (95% CI 72-89%), respectively. This LIDAS instrument gave a lifetime MDD prevalence of 20.8% in the population-based sample. Conclusions Measuring lifetime MDD with an online instrument was feasible. Sensitivity and specificity were adequate. The instrument gave a prevalence of lifetime MDD in line with reported population prevalences. LIDAS is a promising tool for rapid determination of lifetime MDD status in large samples, such as needed for genomics studies.
Original languageEnglish
Pages (from-to)279-289
Number of pages11
JournalPsychological Medicine
Issue number2
Early online date5 Oct 2016
Publication statusPublished - 1 Jan 2017


  • Composite International Diagnostic Interview
  • Journal Article
  • lifetime depression
  • major depressive disorder
  • online questionnaires

Cohort Studies

  • Netherlands Twin Register (NTR)

Cite this