Abstract
We present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels.
Original language | English |
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Pages (from-to) | 94-97 |
Number of pages | 4 |
Journal | International Journal of Epilepsy |
Volume | 4 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2017 |
Keywords
- Congenital malformations
- Pregnancy
- Unbound serum drug levels
- Valproic acid