Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth

Shirley Sparla; Paul Hogeman; Maarten van Gemert; Eleonora Swart; Mirte Malingre

doi:https://doi.org/10.1016/j.ijep.2016.11.001

Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth

Shirley Sparla, Paul Hogeman, Maarten van Gemert, Eleonora Swart, Mirte Malingre

Clinical pharmacology and pharmacy (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

We present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels.

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	International Journal of Epilepsy
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.ijep.2016.11.001
Publication status	Published - 1 Jan 2017

Keywords

Congenital malformations
Pregnancy
Unbound serum drug levels
Valproic acid

Access to Document

https://doi.org/10.1016/j.ijep.2016.11.001

Cite this

@article{119f52b3eae04822bb59110a42b67dae,

title = "Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth",

abstract = "We present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels.",

keywords = "Congenital malformations, Pregnancy, Unbound serum drug levels, Valproic acid",

author = "Shirley Sparla and Paul Hogeman and {van Gemert}, Maarten and Eleonora Swart and Mirte Malingre",

year = "2017",

month = jan,

day = "1",

doi = "https://doi.org/10.1016/j.ijep.2016.11.001",

language = "English",

volume = "4",

pages = "94--97",

journal = "International Journal of Epilepsy",

issn = "2213-6320",

publisher = "Reed-Elsevier (India) Private Limited",

number = "1",

}

Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth. / Sparla, Shirley; Hogeman, Paul; van Gemert, Maarten et al.
In: International Journal of Epilepsy, Vol. 4, No. 1, 01.01.2017, p. 94-97.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Valproic acid during pregnancy

T2 - Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth

AU - Sparla, Shirley

AU - Hogeman, Paul

AU - van Gemert, Maarten

AU - Swart, Eleonora

AU - Malingre, Mirte

PY - 2017/1/1

Y1 - 2017/1/1

N2 - We present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels.

AB - We present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels.

KW - Congenital malformations

KW - Pregnancy

KW - Unbound serum drug levels

KW - Valproic acid

UR - http://www.scopus.com/inward/record.url?scp=85007427065&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.ijep.2016.11.001

DO - https://doi.org/10.1016/j.ijep.2016.11.001

M3 - Article

SN - 2213-6320

VL - 4

SP - 94

EP - 97

JO - International Journal of Epilepsy

JF - International Journal of Epilepsy

IS - 1

ER -

Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth

Abstract

Keywords

Access to Document

Other files and links

Cite this