Vascular stiffening and endothelial dysfunction in atherosclerosis

Aukie Hooglugt, Olivia Klatt, Stephan Huveneers

Research output: Contribution to journalReview articleAcademicpeer-review

17 Citations (Scopus)

Abstract

Purpose of reviewAging is an important risk factor for cardiovascular disease and is associated with increased vessel wall stiffness. Pathophysiological stiffening, notably in arteries, disturbs the integrity of the vascular endothelium and promotes permeability and transmigration of immune cells, thereby driving the development of atherosclerosis and related vascular diseases. Effective therapeutic strategies for arterial stiffening are still lacking.Recent findingsHere, we overview the literature on age-related arterial stiffening, from patient-derived data to preclinical in-vivo and in-vitro findings. First, we overview the common techniques that are used to measure stiffness and discuss the observed stiffness values in atherosclerosis and aging. Next, the endothelial response to stiffening and possibilities to attenuate this response are discussed.SummaryFuture research that will define the endothelial contribution to stiffness-related cardiovascular disease may provide new targets for intervention to restore endothelial function in atherosclerosis and complement the use of currently applied lipid-lowering, antihypertensive, and anti-inflammatory drugs.
Original languageEnglish
Pages (from-to)353-363
Number of pages11
JournalCurrent opinion in lipidology
Volume33
Issue number6
DOIs
Publication statusPublished - 1 Dec 2022

Keywords

  • Aging
  • atherosclerosis
  • endothelium
  • mechanotransduction
  • stiffness

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