Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report

Alje P. van Dam; Marc L. van Ogtrop; Daniel Golparian; Jan Mehrtens; Henry J. C. de Vries; Magnus Unemo

doi:https://doi.org/10.1136/sextrans-2014-051552

Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report

Alje P. van Dam, Marc L. van Ogtrop, Daniel Golparian, Jan Mehrtens, Henry J. C. de Vries, Magnus Unemo

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally spreading multidrug-resistant gonococcal NG-MAST ST1407 clone. The patient was clinically cured after treatment with ceftriaxone 500 mg intramuscularly and this is the only third generation cephalosporin that should be used for first-line empiric treatment of gonorrhoea. Increased awareness of failures with third generation cephalosporins, enhanced monitoring and appropriate verification of treatment failures including more frequent test-of-cures, and strict adherence to regularly updated treatment guidelines are essential globally

Original language	English
Pages (from-to)	513-514
Journal	Sexually transmitted infections
Volume	90
Issue number	7
DOIs	https://doi.org/10.1136/sextrans-2014-051552
Publication status	Published - 2014

Access to Document

https://doi.org/10.1136/sextrans-2014-051552

Cite this

@article{997e67ff650b4553a947cb46700dc3d7,

title = "Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report",

abstract = "We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally spreading multidrug-resistant gonococcal NG-MAST ST1407 clone. The patient was clinically cured after treatment with ceftriaxone 500 mg intramuscularly and this is the only third generation cephalosporin that should be used for first-line empiric treatment of gonorrhoea. Increased awareness of failures with third generation cephalosporins, enhanced monitoring and appropriate verification of treatment failures including more frequent test-of-cures, and strict adherence to regularly updated treatment guidelines are essential globally",

author = "{van Dam}, {Alje P.} and {van Ogtrop}, {Marc L.} and Daniel Golparian and Jan Mehrtens and {de Vries}, {Henry J. C.} and Magnus Unemo",

year = "2014",

doi = "https://doi.org/10.1136/sextrans-2014-051552",

language = "English",

volume = "90",

pages = "513--514",

journal = "Sexually transmitted infections",

issn = "1368-4973",

publisher = "BMJ Publishing Group",

number = "7",

}

TY - JOUR

T1 - Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report

AU - van Dam, Alje P.

AU - van Ogtrop, Marc L.

AU - Golparian, Daniel

AU - Mehrtens, Jan

AU - de Vries, Henry J. C.

AU - Unemo, Magnus

PY - 2014

Y1 - 2014

N2 - We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally spreading multidrug-resistant gonococcal NG-MAST ST1407 clone. The patient was clinically cured after treatment with ceftriaxone 500 mg intramuscularly and this is the only third generation cephalosporin that should be used for first-line empiric treatment of gonorrhoea. Increased awareness of failures with third generation cephalosporins, enhanced monitoring and appropriate verification of treatment failures including more frequent test-of-cures, and strict adherence to regularly updated treatment guidelines are essential globally

AB - We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally spreading multidrug-resistant gonococcal NG-MAST ST1407 clone. The patient was clinically cured after treatment with ceftriaxone 500 mg intramuscularly and this is the only third generation cephalosporin that should be used for first-line empiric treatment of gonorrhoea. Increased awareness of failures with third generation cephalosporins, enhanced monitoring and appropriate verification of treatment failures including more frequent test-of-cures, and strict adherence to regularly updated treatment guidelines are essential globally

U2 - https://doi.org/10.1136/sextrans-2014-051552

DO - https://doi.org/10.1136/sextrans-2014-051552

M3 - Article

C2 - 25114322

SN - 1368-4973

VL - 90

SP - 513

EP - 514

JO - Sexually transmitted infections

JF - Sexually transmitted infections

IS - 7

ER -