TY - JOUR
T1 - Virus discovery in chronic inflammatory demyelinating polyneuropathy
AU - van Lieverloo, G. G.A.
AU - Wieske, L.
AU - van Schaik, I. N.
AU - Deijs, M.
AU - van der Hoek, L.
AU - Eftimov, F.
N1 - Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/9/15
Y1 - 2021/9/15
N2 - The events triggering and/or sustaining the auto-immune response underlying chronic inflammatory demyelinating polyneuropathy (CIDP) are unknown. Similar to Guillain-Barré syndrome (GBS), a viral infection might play a role in CIDP. In this study, an virus detection method (VIDISCA-next generation sequencing) capable of detecting known and unknown viruses, was used to analyze the virome in serum of 47 CIDP patients at different time points of the disease and, when available, in cerebrospinal fluid (CSF) samples (N: 17). Serum samples of GBS patients (N:24) and healthy controls (N:114) were used for comparisons. In 5/47 (10.6%; 95% CI: 4–23) CIDP samples, 10/24 (42%; 95% CI: 22–63) GBS samples and 32/114 (28.1%; 95% CI: 20–37) healthy controls samples, anelloviruses were detected, generally regarded as a non-pathogenic species. Parvovirus B19 and GB virus C were found in two CIDP samples (4%). Parvovirus B19, HIV-1 and GB virus C were found in three GBS samples (13%). In 2/17 CIDP CSF samples, an anellovirus and polyomavirus were detected, probably due to contamination during lumbar puncture. No sequences of other viruses were detected in serum or CSF. A (persistent) viral infection sustaining the auto-immune response in CIDP seems therefore unlikely.
AB - The events triggering and/or sustaining the auto-immune response underlying chronic inflammatory demyelinating polyneuropathy (CIDP) are unknown. Similar to Guillain-Barré syndrome (GBS), a viral infection might play a role in CIDP. In this study, an virus detection method (VIDISCA-next generation sequencing) capable of detecting known and unknown viruses, was used to analyze the virome in serum of 47 CIDP patients at different time points of the disease and, when available, in cerebrospinal fluid (CSF) samples (N: 17). Serum samples of GBS patients (N:24) and healthy controls (N:114) were used for comparisons. In 5/47 (10.6%; 95% CI: 4–23) CIDP samples, 10/24 (42%; 95% CI: 22–63) GBS samples and 32/114 (28.1%; 95% CI: 20–37) healthy controls samples, anelloviruses were detected, generally regarded as a non-pathogenic species. Parvovirus B19 and GB virus C were found in two CIDP samples (4%). Parvovirus B19, HIV-1 and GB virus C were found in three GBS samples (13%). In 2/17 CIDP CSF samples, an anellovirus and polyomavirus were detected, probably due to contamination during lumbar puncture. No sequences of other viruses were detected in serum or CSF. A (persistent) viral infection sustaining the auto-immune response in CIDP seems therefore unlikely.
KW - Chronic inflammatory demyelinating polyneuropathy
KW - Guillain Barré syndrome
KW - Next generation sequencing
KW - VIDISCA
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85111195650&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jneuroim.2021.577668
DO - https://doi.org/10.1016/j.jneuroim.2021.577668
M3 - Article
C2 - 34325344
SN - 0165-5728
VL - 358
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577668
ER -