TY - JOUR
T1 - Visualization of DNA double-strand break repair: From molecules to cells
AU - Krawczyk, Przemek M.
AU - Stap, Jan
AU - Aten, Jacob A.
PY - 2008
Y1 - 2008
N2 - DNA double-strand break (DSB) signaling and repair processes are positioned at the crossroad of nuclear pathways that regulate DNA replication, cell division, senescence and apoptosis. Importantly, errors in DSB repair may lead to lethal or potentially tumorigenic chromosome rearrangements. Therefore, understanding cellular DSB response mechanisms is important for both cancer prevention and treatment. Visualization of DSB repair proteins, both at the level of single molecules and at the level of cells and tissues is a powerful tool in unraveling DNA damage response. This review summarizes several available techniques for visualization of DSB repair proteins and describes types of information that can be obtained using these techniques
AB - DNA double-strand break (DSB) signaling and repair processes are positioned at the crossroad of nuclear pathways that regulate DNA replication, cell division, senescence and apoptosis. Importantly, errors in DSB repair may lead to lethal or potentially tumorigenic chromosome rearrangements. Therefore, understanding cellular DSB response mechanisms is important for both cancer prevention and treatment. Visualization of DSB repair proteins, both at the level of single molecules and at the level of cells and tissues is a powerful tool in unraveling DNA damage response. This review summarizes several available techniques for visualization of DSB repair proteins and describes types of information that can be obtained using these techniques
U2 - https://doi.org/10.2174/157340508785294543
DO - https://doi.org/10.2174/157340508785294543
M3 - Review article
SN - 1573-4056
VL - 4
SP - 202
EP - 211
JO - Current medical imaging reviews
JF - Current medical imaging reviews
IS - 3
ER -