TY - JOUR
T1 - Vitamin B-6 vitamers in human plasma and cerebrospinal fluid
AU - Albersen, Monique
AU - Bosma, Marjolein
AU - Luykx, Jurjen J.
AU - Jans, Judith J.M.
AU - Bakker, Steven C.
AU - Strengman, Eric
AU - Borgdorff, Paul J.
AU - Keijzers, Peter J.M.
AU - Van Dongen, Eric P.A.
AU - Bruins, Peter
AU - De Sain-Van Der Velden, Monique G.M.
AU - Visser, Gepke
AU - Knoers, Nine V.V.A.M.
AU - Ophoff, Roel A.
AU - Verhoeven-Duif, Nanda M.
PY - 2014
Y1 - 2014
N2 - Background: Vitamin B-6 comprises a group of 6 interrelated vi-tamers and is essential for numerous physiologic processes, including brain functioning. Genetic disorders disrupting vitamin B-6 metabolism have severe clinical consequences. Objective: To adequately diagnose known and novel disorders in vitamin B-6 metabolism, a reference set is required containing information on all vitamin B-6 vitamers in plasma and cerebrospinal fluid (CSF). Design: Concentrations of vitamin B-6 vitamers in the plasma and CSF of 533 adult subjects were measured by ultra high-performance liquid chromatography-tandem mass spectrometry. Results: The relative vitamin B-6 vitamer composition of plasma [pyridoxal phosphate (PLP) > pyridoxic acid (PA) > pyridoxal] differed from that of CSF (pyridoxal > PLP > PA > pyridoxamine). Sex influenced vitamin B-6 vitamer concentrations in plasma and CSF and should therefore be taken into account when interpreting vitamin B-6 vitamer concentrations. The strict ratios and strong correlations between vitamin B-6 vitamers point to a tight regulation of vitamin B-6 vitamer concentrations in blood and CSF. Given the unique design of this study, with simultaneously withdrawn blood and CSF from a large number of subjects, reliable CSF: plasma ratios and correlations of vitamin B-6 vitamers could be established. Conclusions: We provide an extensive reference set of vitamin B-6 vitamer concentrations in plasma and CSF. In addition to providing insight on the regulation of individual vitamers and their intercom-partmental distribution, we anticipate that these data will prove to be a valuable reference set for the diagnosis and treatment of conditions associated with altered vitamin B-6 metabolism.
AB - Background: Vitamin B-6 comprises a group of 6 interrelated vi-tamers and is essential for numerous physiologic processes, including brain functioning. Genetic disorders disrupting vitamin B-6 metabolism have severe clinical consequences. Objective: To adequately diagnose known and novel disorders in vitamin B-6 metabolism, a reference set is required containing information on all vitamin B-6 vitamers in plasma and cerebrospinal fluid (CSF). Design: Concentrations of vitamin B-6 vitamers in the plasma and CSF of 533 adult subjects were measured by ultra high-performance liquid chromatography-tandem mass spectrometry. Results: The relative vitamin B-6 vitamer composition of plasma [pyridoxal phosphate (PLP) > pyridoxic acid (PA) > pyridoxal] differed from that of CSF (pyridoxal > PLP > PA > pyridoxamine). Sex influenced vitamin B-6 vitamer concentrations in plasma and CSF and should therefore be taken into account when interpreting vitamin B-6 vitamer concentrations. The strict ratios and strong correlations between vitamin B-6 vitamers point to a tight regulation of vitamin B-6 vitamer concentrations in blood and CSF. Given the unique design of this study, with simultaneously withdrawn blood and CSF from a large number of subjects, reliable CSF: plasma ratios and correlations of vitamin B-6 vitamers could be established. Conclusions: We provide an extensive reference set of vitamin B-6 vitamer concentrations in plasma and CSF. In addition to providing insight on the regulation of individual vitamers and their intercom-partmental distribution, we anticipate that these data will prove to be a valuable reference set for the diagnosis and treatment of conditions associated with altered vitamin B-6 metabolism.
UR - http://www.scopus.com/inward/record.url?scp=84905377079&partnerID=8YFLogxK
U2 - 10.3945/ajcn.113.082008
DO - 10.3945/ajcn.113.082008
M3 - Article
C2 - 24808484
SN - 0002-9165
VL - 100
SP - 587
EP - 592
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -