TY - JOUR
T1 - Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease
AU - van der Land, Veronica
AU - Hijmans, Channa T.
AU - de Ruiter, Marieke
AU - Mutsaerts, Henri J.M.M.
AU - Cnossen, Marjon H.
AU - Engelen, Marc
AU - Majoie, Charles B.L.M.
AU - Nederveen, Aart J.
AU - Grootenhuis, Martha A.
AU - Fijnvandraat, Karin
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Summary: Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.
AB - Summary: Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.
KW - Neurocognitive functioning
KW - Sickle cell disease
KW - Silent cerebral infarcts
UR - http://www.scopus.com/inward/record.url?scp=84923107854&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/bjh.13179
DO - https://doi.org/10.1111/bjh.13179
M3 - Article
C2 - 25303108
SN - 0007-1048
VL - 168
SP - 553
EP - 556
JO - British journal of haematology
JF - British journal of haematology
IS - 4
ER -