TY - JOUR
T1 - Ways forward for tolerance-inducing cellular therapies- An afactt perspective
AU - ten Brinke, Anja
AU - Martinez-Llordella, Marc
AU - Cools, Nathalie
AU - Hilkens, Catharien M. U.
AU - van Ham, S. Marieke
AU - Sawitzki, Birgit
AU - Geissler, Edward K.
AU - Lombardi, Giovanna
AU - Trzonkowski, Piotr
AU - Martinez-Caceres, Eva
PY - 2019/2/22
Y1 - 2019/2/22
N2 - Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.
AB - Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.
KW - Animals
KW - Antigen-Presenting Cells/immunology
KW - Autoimmunity
KW - Biomarkers
KW - Cell- and Tissue-Based Therapy/methods
KW - Clinical Studies as Topic
KW - Dendritic Cells/immunology
KW - Humans
KW - Immune Tolerance
KW - Immunomodulation
KW - Immunophenotyping
KW - Immunotherapy
KW - T-Lymphocyte Subsets/immunology
KW - T-Lymphocytes, Regulatory/immunology
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062729346&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30853957
U2 - https://doi.org/10.3389/fimmu.2019.00181
DO - https://doi.org/10.3389/fimmu.2019.00181
M3 - Article
C2 - 30853957
SN - 1664-3224
VL - 10
JO - Frontiers in immunology
JF - Frontiers in immunology
IS - FEB
M1 - 181
ER -