Weefselresidente t-geheugencellen in vitiligo en melanoom

Tissue-resident memory T (TRM) cells function as alarming sensors providing a long-term local memory that can spread widely when re-infected with the same antigen or when suppressing cancer. However, when dysfunctional, skin located TRM cells can have a profound role in various skin disorders, including psoriasis, allergic contact dermati-tis, cutaneous T cell lymphoma and vitiligo. Therefore, targeting TRM cells appears to be an attractive treatment strategy for vitiligo. The evidence on the contribution of TRM cells in cancer suppression also shows how the mani-pulation of TRM cells can be beneficial in optimizing the anti-tumor immunity. Vaccination strategies have success-fully generated TRM cell populations that have effectively suppressed tumor growth in mouse models of melanoma. With more knowledge becoming available on the involve-ment of TRM cells in autoimmunity and cancer, future research will hopefully overcome barriers to effectively block or to promote effective responses of TRM cells to vitiligo and melanoma.