TY - JOUR
T1 - White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells
AU - Hsiao, C.-C.
AU - Fransen, N.L.
AU - van den Bosch, A.M.R.
AU - Brandwijk, K.I.M.
AU - Huitinga, I.
AU - Hamann, J.
AU - Smolders, J.
N1 - - With supporting information.
PY - 2021/2
Y1 - 2021/2
N2 - Brain CD8+ CD69+ tissue-resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.
AB - Brain CD8+ CD69+ tissue-resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.
KW - CD20
KW - brain
KW - human
KW - multiple sclerosis
KW - tissue-resident memory T cells
UR - https://pure.uva.nl/ws/files/63298461/eji4910_sup_0001_suppmat.docx
UR - http://www.scopus.com/inward/record.url?scp=85092398007&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/eji.202048665
DO - https://doi.org/10.1002/eji.202048665
M3 - Comment/Letter to the editor
C2 - 32949467
SN - 0014-2980
VL - 51
SP - 483
EP - 486
JO - European journal of immunology
JF - European journal of immunology
IS - 2
ER -