Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT

Katrijn Michielsen; Ignace Vergote; Katya Op de Beeck; Frederic Amant; Karin Leunen; Philippe Moerman; Christophe Deroose; Geert Souverijns; Steven Dymarkowski; Frederik de Keyzer; Vincent Vandecaveye

doi:https://doi.org/10.1007/s00330-013-3083-8

Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT

Katrijn Michielsen, Ignace Vergote, Katya Op de Beeck, Frederic Amant, Karin Leunen, Philippe Moerman, Christophe Deroose, Geert Souverijns, Steven Dymarkowski, Frederik de Keyzer, Vincent Vandecaveye

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Research output: Contribution to journal › Article › Academic › peer-review

174 Citations (Scopus)

Abstract

To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer. Thirty-two patients underwent 3-T WB-DWI/MRI, (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined. WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (kappa = 1.00) for detecting distant metastases compared with CT (kappa = 0.34). Interobserver agreement was moderate to almost perfect (kappa = 0.58-0.91). WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients. aEuro cent Whole-body MRI with diffusion weighting (WB-DWI/MRI) helps to assess the operability of suspected ovarian cancer. aEuro cent Interobserver agreement is good for primary tumour characterisation, peritoneal and distant staging. aEuro cent WB-DWI/MRI improves mesenteric/serosal metastatic spread assessment compared with CT and FDG-PET/CT. aEuro cent Retroperitoneal/cervical-thoracic nodal staging using qualitative DWI criteria was reasonably accurate. aEuro cent WB-DWI/MRI and FDG-PET/CT showed the highest diagnostic impact for detecting thoracic metastases

Original language	English
Pages (from-to)	889-901
Journal	European Radiology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s00330-013-3083-8
Publication status	Published - 2014

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https://doi.org/10.1007/s00330-013-3083-8

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Michielsen, K., Vergote, I., Op de Beeck, K., Amant, F., Leunen, K., Moerman, P., Deroose, C., Souverijns, G., Dymarkowski, S., de Keyzer, F., & Vandecaveye, V. (2014). Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT. European Radiology, 24(4), 889-901. https://doi.org/10.1007/s00330-013-3083-8

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title = "Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT",

abstract = "To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer. Thirty-two patients underwent 3-T WB-DWI/MRI, (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined. WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (kappa = 1.00) for detecting distant metastases compared with CT (kappa = 0.34). Interobserver agreement was moderate to almost perfect (kappa = 0.58-0.91). WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients. aEuro cent Whole-body MRI with diffusion weighting (WB-DWI/MRI) helps to assess the operability of suspected ovarian cancer. aEuro cent Interobserver agreement is good for primary tumour characterisation, peritoneal and distant staging. aEuro cent WB-DWI/MRI improves mesenteric/serosal metastatic spread assessment compared with CT and FDG-PET/CT. aEuro cent Retroperitoneal/cervical-thoracic nodal staging using qualitative DWI criteria was reasonably accurate. aEuro cent WB-DWI/MRI and FDG-PET/CT showed the highest diagnostic impact for detecting thoracic metastases",

author = "Katrijn Michielsen and Ignace Vergote and {Op de Beeck}, Katya and Frederic Amant and Karin Leunen and Philippe Moerman and Christophe Deroose and Geert Souverijns and Steven Dymarkowski and {de Keyzer}, Frederik and Vincent Vandecaveye",

year = "2014",

doi = "https://doi.org/10.1007/s00330-013-3083-8",

language = "English",

volume = "24",

pages = "889--901",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "4",

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Michielsen, K, Vergote, I, Op de Beeck, K, Amant, F, Leunen, K, Moerman, P, Deroose, C, Souverijns, G, Dymarkowski, S, de Keyzer, F & Vandecaveye, V 2014, 'Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT', European Radiology, vol. 24, no. 4, pp. 889-901. https://doi.org/10.1007/s00330-013-3083-8

Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT. / Michielsen, Katrijn; Vergote, Ignace; Op de Beeck, Katya et al.
In: European Radiology, Vol. 24, No. 4, 2014, p. 889-901.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Whole-body MRI with diffusion-weighted sequence for staging of patients with suspected ovarian cancer: a clinical feasibility study in comparison to CT and FDG-PET/CT

AU - Michielsen, Katrijn

AU - Vergote, Ignace

AU - Op de Beeck, Katya

AU - Amant, Frederic

AU - Leunen, Karin

AU - Moerman, Philippe

AU - Deroose, Christophe

AU - Souverijns, Geert

AU - Dymarkowski, Steven

AU - de Keyzer, Frederik

AU - Vandecaveye, Vincent

PY - 2014

Y1 - 2014

N2 - To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer. Thirty-two patients underwent 3-T WB-DWI/MRI, (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined. WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (kappa = 1.00) for detecting distant metastases compared with CT (kappa = 0.34). Interobserver agreement was moderate to almost perfect (kappa = 0.58-0.91). WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients. aEuro cent Whole-body MRI with diffusion weighting (WB-DWI/MRI) helps to assess the operability of suspected ovarian cancer. aEuro cent Interobserver agreement is good for primary tumour characterisation, peritoneal and distant staging. aEuro cent WB-DWI/MRI improves mesenteric/serosal metastatic spread assessment compared with CT and FDG-PET/CT. aEuro cent Retroperitoneal/cervical-thoracic nodal staging using qualitative DWI criteria was reasonably accurate. aEuro cent WB-DWI/MRI and FDG-PET/CT showed the highest diagnostic impact for detecting thoracic metastases

AB - To evaluate whole-body MRI with diffusion-weighted sequence (WB-DWI/MRI) for staging and assessing operability compared with CT and FDG-PET/CT in patients with suspected ovarian cancer. Thirty-two patients underwent 3-T WB-DWI/MRI, (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and CT before diagnostic open laparoscopy (DOL). Imaging findings for tumour characterisation, peritoneal and retroperitoneal staging were correlated with histopathology after DOL and/or open surgery. For distant metastases, FDG-PET/CT or image-guided biopsies were the reference standards. For tumour characterisation and peritoneal staging, WB-DWI/MRI was compared with CT and FDG-PET/CT. Interobserver agreement for WB-DWI/MRI was determined. WB-DWI/MRI showed 94 % accuracy for primary tumour characterisation compared with 88 % for CT and 94 % for FDG-PET/CT. WB-DWI/MRI showed higher accuracy of 91 % for peritoneal staging compared with CT (75 %) and FDG-PET/CT (71 %). WB-DWI/MRI and FDG-PET/CT showed higher accuracy of 87 % for detecting retroperitoneal lymphadenopathies compared with CT (71 %). WB-DWI/MRI showed excellent correlation with FDG-PET/CT (kappa = 1.00) for detecting distant metastases compared with CT (kappa = 0.34). Interobserver agreement was moderate to almost perfect (kappa = 0.58-0.91). WB-DWI/MRI shows high accuracy for characterising primary tumours, peritoneal and distant staging compared with CT and FDG-PET/CT and may be valuable for assessing operability in ovarian cancer patients. aEuro cent Whole-body MRI with diffusion weighting (WB-DWI/MRI) helps to assess the operability of suspected ovarian cancer. aEuro cent Interobserver agreement is good for primary tumour characterisation, peritoneal and distant staging. aEuro cent WB-DWI/MRI improves mesenteric/serosal metastatic spread assessment compared with CT and FDG-PET/CT. aEuro cent Retroperitoneal/cervical-thoracic nodal staging using qualitative DWI criteria was reasonably accurate. aEuro cent WB-DWI/MRI and FDG-PET/CT showed the highest diagnostic impact for detecting thoracic metastases

U2 - https://doi.org/10.1007/s00330-013-3083-8

DO - https://doi.org/10.1007/s00330-013-3083-8

M3 - Article

C2 - 24322510

SN - 0938-7994

VL - 24

SP - 889

EP - 901

JO - European Radiology

JF - European Radiology

IS - 4

ER -