@article{760de372eace439e909214294a981992,
title = "Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer",
abstract = "PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.",
author = "Niemeijer, {A. N.} and D. Leung and Huisman, {M. C.} and I. Bahce and Hoekstra, {O. S.} and {van Dongen}, {G. A.M.S.} and R. Boellaard and S. Du and W. Hayes and R. Smith and Windhorst, {A. D.} and Hendrikse, {N. H.} and A. Poot and Vugts, {D. J.} and E. Thunnissen and P. Morin and D. Lipovsek and Donnelly, {D. J.} and Bonacorsi, {S. J.} and Velasquez, {L. M.} and {de Gruijl}, {T. D.} and Smit, {E. F.} and {de Langen}, {A. J.}",
year = "2018",
month = dec,
day = "1",
doi = "https://doi.org/10.1038/s41467-018-07131-y",
language = "English",
volume = "9",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}