TY - JOUR
T1 - Whole-brain functional connectivity during emotional word classification in medication-free Major Depressive Disorder
T2 - Abnormal salience circuitry and relations to positive emotionality
AU - Van Tol, Marie José
AU - Veer, Ilya M.
AU - Van Der Wee, Nic J.A.
AU - Aleman, André
AU - Van Buchem, Mark A.
AU - Rombouts, Serge A.R.B.
AU - Zitman, Frans G.
AU - Veltman, Dick J.
AU - Johnstone, Tom
N1 - Funding Information: This work was supported by the NESDA infrastructure ( www.nesda.nl ), which is funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (Zon-Mw, grant number 10-000-1002) and is supported by participating universities and mental health care organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for Quality of Healthcare (IQ healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos Institute)). S.A.R.B. Rombouts is the recipient of a (VIDI) grant from The Netherlands Organization for Scientific Research (NWO, grant number917 863 68). The Erasmus staff exchange program is acknowledged for making the collaboration between M.J. van Tol and T. Johnstone possible. Funding Information: M.J. van Tol, I.M. Veer, S.A.R.B. Rombouts, D.J. Veltman, M.A. van Buchem, F.G. Zitman, and I.T. Johnstone report no financial interests or potential conflicts of interest. A. Aleman received an investigator-initiated unrestricted research grant from Brystol-Myers Squibb and speakers bureau honoraria from AstraZeneca, Brystol-Myers Squibb, GlaxoSmithKline and Janssen. N.J.A. van der Wee received speaking fees from Eli Lilly and Wyeth; and served on advisory panels of Eli LIlly, Pfizer, Wyeth and Servier.
PY - 2013
Y1 - 2013
N2 - Major Depressive Disorder (MDD) has been associated with biased processing and abnormal regulation of negative and positive information, which may result from compromised coordinated activity of prefrontal and subcortical brain regions involved in evaluating emotional information. We tested whether patients with MDD show distributed changes in functional connectivity with a set of independently derived brain networks that have shown high correspondence with different task demands, including stimulus salience and emotional processing. We further explored if connectivity during emotional word processing related to the tendency to engage in positive or negative emotional states. In this study, 25 medication-free MDD patients without current or past comorbidity and matched controls (n = 25) performed an emotional word-evaluation task during functional MRI. Using a dual regression approach, individual spatial connectivity maps representing each subject's connectivity with each standard network were used to evaluate between-group differences and effects of positive and negative emotionality (extraversion and neuroticism, respectively, as measured with the NEO-FFI). Results showed decreased functional connectivity of the medial prefrontal cortex, ventrolateral prefrontal cortex, and ventral striatum with the fronto-opercular salience network in MDD patients compared to controls. In patients, abnormal connectivity was related to extraversion, but not neuroticism. These results confirm the hypothesis of a relative (para)limbic-cortical decoupling that may explain dysregulated affect in MDD. As connectivity of these regions with the salience network was related to extraversion, but not to general depression severity or negative emotionality, dysfunction of this network may be responsible for the failure to sustain engagement in rewarding behavior.
AB - Major Depressive Disorder (MDD) has been associated with biased processing and abnormal regulation of negative and positive information, which may result from compromised coordinated activity of prefrontal and subcortical brain regions involved in evaluating emotional information. We tested whether patients with MDD show distributed changes in functional connectivity with a set of independently derived brain networks that have shown high correspondence with different task demands, including stimulus salience and emotional processing. We further explored if connectivity during emotional word processing related to the tendency to engage in positive or negative emotional states. In this study, 25 medication-free MDD patients without current or past comorbidity and matched controls (n = 25) performed an emotional word-evaluation task during functional MRI. Using a dual regression approach, individual spatial connectivity maps representing each subject's connectivity with each standard network were used to evaluate between-group differences and effects of positive and negative emotionality (extraversion and neuroticism, respectively, as measured with the NEO-FFI). Results showed decreased functional connectivity of the medial prefrontal cortex, ventrolateral prefrontal cortex, and ventral striatum with the fronto-opercular salience network in MDD patients compared to controls. In patients, abnormal connectivity was related to extraversion, but not neuroticism. These results confirm the hypothesis of a relative (para)limbic-cortical decoupling that may explain dysregulated affect in MDD. As connectivity of these regions with the salience network was related to extraversion, but not to general depression severity or negative emotionality, dysfunction of this network may be responsible for the failure to sustain engagement in rewarding behavior.
KW - Depression
KW - Extraversion
KW - Functional magnetic resonance imagint
KW - Salience network
KW - Whole-brain functional connectivity
UR - http://www.scopus.com/inward/record.url?scp=84879906596&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2013.05.012
DO - https://doi.org/10.1016/j.nicl.2013.05.012
M3 - Article
C2 - 24179829
SN - 2213-1582
VL - 2
SP - 790
EP - 796
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
IS - 1
ER -