@article{229e97ba2d9c4f5c979a379e3b0bde1f,
title = "Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis",
abstract = "Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.",
keywords = "Purkinje, ablation, arrhythmias, early repolarization syndrome, electrophysiology, idiopathic ventricular fibrillation",
author = "Ruben Coronel and Mark Potse and Michel Ha{\"i}ssaguerre and Nicolas Derval and Rivaud, {Mathilde R.} and Meijborg, {Veronique M. F.} and Matthijs Cluitmans and Hocini, {M. l{\`e}ze} and Boukens, {Bastiaan J.}",
note = "Funding Information: Funding. This work was supported by Leducq transatlantic network of excellence (RHYTHM, 16CVD02; RC, MHa). BB received support from the Dutch heart foundation (2016T047). This work was granted access to HPC resources of CINES under GENCI allocation 2019-A0030307379. This work was supported by the National Research Agency; grant reference ANR-10-IAHU04-LIRYC. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Coronel, Potse, Ha{\"i}ssaguerre, Derval, Rivaud, Meijborg, Cluitmans, Hocini and Boukens.",
year = "2021",
month = mar,
day = "23",
doi = "https://doi.org/10.3389/fphys.2021.648396",
language = "English",
volume = "12",
journal = "Frontiers in physiology",
issn = "1664-042X",
publisher = "Frontiers Media S.A.",
}