Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius

Alice Wegener; Birgitta Duim; Linda van der Graaf-van Bloois; Aldert L. Zomer; Caroline E. Visser; Mirlin Spaninks; Arjen J. Timmerman; Jaap A. Wagenaar; Els M. Broens

doi:https://doi.org/10.3390/pathogens11080850

Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius

Alice Wegener, Birgitta Duim, Linda van der Graaf-van Bloois, Aldert L. Zomer, Caroline E. Visser, Mirlin Spaninks, Arjen J. Timmerman, Jaap A. Wagenaar, Els M. Broens

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.

Original language	English
Article number	850
Journal	Pathogens
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/pathogens11080850
Publication status	Published - 1 Aug 2022

Keywords

One health
S. pseudintermedius
bacterial diversity
transmission
whole genome sequencing
zoonotic

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https://doi.org/10.3390/pathogens11080850

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title = "Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius",

abstract = "Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.",

keywords = "One health, S. pseudintermedius, bacterial diversity, transmission, whole genome sequencing, zoonotic",

author = "Alice Wegener and Birgitta Duim and {van der Graaf-van Bloois}, Linda and Zomer, {Aldert L.} and Visser, {Caroline E.} and Mirlin Spaninks and Timmerman, {Arjen J.} and Wagenaar, {Jaap A.} and Broens, {Els M.}",

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AU - Wegener, Alice

AU - Duim, Birgitta

AU - van der Graaf-van Bloois, Linda

AU - Zomer, Aldert L.

AU - Visser, Caroline E.

AU - Spaninks, Mirlin

AU - Timmerman, Arjen J.

AU - Wagenaar, Jaap A.

AU - Broens, Els M.

PY - 2022/8/1

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N2 - Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.

AB - Staphylococcus pseudintermedius can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in S. pseudintermedius, demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.

KW - One health

KW - S. pseudintermedius

KW - bacterial diversity

KW - transmission

KW - whole genome sequencing

KW - zoonotic

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SN - 2076-0817

VL - 11

JO - Pathogens

JF - Pathogens

IS - 8

M1 - 850

ER -

Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius

Abstract

Keywords

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