@article{3384efa194ac4f97a0b1d5b7d14b4cee,
title = "Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes",
abstract = "Deriving a large number of hiPSC-cardiomyocytes would be beneficial for large-scale tissue engineering and drug screening applications. Buikema et al. show that GSK-3β inhibition combined with removal of cell-cell contact enables massive expansion of hiPSC-cardiomyocytes with comparable function to non-expanded cells.",
keywords = "GSK3, Wnt signaling, cardiomyocytes, expansion, induced pluripotent stem cells, maturation, proliferation",
author = "Buikema, {Jan W.} and Soah Lee and Goodyer, {William R.} and Maas, {Renee G.} and Orlando Chirikian and Guang Li and Yi Miao and Paige, {Sharon L.} and Daniel Lee and Haodi Wu and Paik, {David T.} and Siyeon Rhee and Lei Tian and Galdos, {Francisco X.} and Nazan Puluca and Benjamin Beyersdorf and James Hu and Aimee Beck and Sneha Venkamatran and Srilatha Swami and Paul Wijnker and Maike Schuldt and Dorsch, {Larissa M.} and {van Mil}, Alain and Kristy Red-Horse and Wu, {Joy Y.} and Caroline Geisen and Michael Hesse and Vahid Serpooshan and Stefan Jovinge and Fleischmann, {Bernd K.} and Doevendans, {Pieter A.} and {van der Velden}, Jolanda and Garcia, {K. Christopher} and Wu, {Joseph C.} and Sluijter, {Joost P.G.} and Wu, {Sean M.}",
year = "2020",
month = jul,
day = "2",
doi = "https://doi.org/10.1016/j.stem.2020.06.001",
language = "English",
volume = "27",
pages = "50--63",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "1",
}