Zebrafish as potential model for developmental neurotoxicity testing. A mini review

Celine De Esch; Roderick Slieker; André Wolterbeek; Ruud Woutersen; Didima de Groot

doi:https://doi.org/10.1016/j.ntt.2012.08.006

Zebrafish as potential model for developmental neurotoxicity testing. A mini review

Celine De Esch, Roderick Slieker, André Wolterbeek, Ruud Woutersen, Didima de Groot

Research output: Contribution to journal › Review article › Academic › peer-review

152 Citations (Scopus)

Abstract

The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use.

Original language	English
Pages (from-to)	545-553
Number of pages	9
Journal	Neurotoxicology and Teratology
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/j.ntt.2012.08.006
Publication status	Published - 1 Nov 2012

Keywords

Developmental neurotoxicity
Model
Toxicity screening
Zebrafish

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https://doi.org/10.1016/j.ntt.2012.08.006

Cite this

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AU - de Groot, Didima

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KW - Model

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Zebrafish as potential model for developmental neurotoxicity testing. A mini review

Abstract

Keywords

Access to Document

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