Zebrafish as potential model for developmental neurotoxicity testing. A mini review

Celine De Esch, Roderick Slieker, André Wolterbeek, Ruud Woutersen, Didima de Groot

Research output: Contribution to journalReview articleAcademicpeer-review

157 Citations (Scopus)


The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use.

Original languageEnglish
Pages (from-to)545-553
Number of pages9
JournalNeurotoxicology and Teratology
Issue number6
Publication statusPublished - 1 Nov 2012


  • Developmental neurotoxicity
  • Model
  • Toxicity screening
  • Zebrafish

Cite this