ZIDOVUDINETHERAPIE BIJ 141 PATIENTEN MET SIJMPTOMEN VAN HIV-INFECTIE; EEN MULTI-CENTRA-ONDERZOEK

Translated title of the contribution: Zidovudine therapy in 141 patients with symptoms of HIV infection; a multicentre study

R. Perenboom, P. Reiss, S. A. Danner, J. W. Van 'T Wout

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Abstract

We describe the results of treatment with zidovudine in 141 symptomatic HIV positive patients, 119 of whom had AIDS. Total mortality was 30% over a mean observation period of 45 weeks after the start of the treatment. This is much lower than the mortality among AIDS patients in the pre-zidovudine period. During the first 2 months the feeling of wellbeing and the body weight increased, but after 4 months these effects declined. Two months after start of therapy the number of new opportunistic infections declined, but it increased thereafter. Side effects were frequent: after 7 months zidovudine had to be reduced or even stopped in 43% of the patients mostly because of anaemia and/or leukopenia. After 6-7 months 45% of all patients had been given packed cells transfusions with a mean of 16 units. In general tolerability of zidovudine was better in patients with a higher number of circulating CD4-positive cells at the start. These results confirm that the effect of zidovudine in symptomatic HIV infected patients is favourable but only of limited duration
Translated title of the contributionZidovudine therapy in 141 patients with symptoms of HIV infection; a multicentre study
Original languageDutch
Pages (from-to)120-124
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Volume134
Issue number3
Publication statusPublished - 1990

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