TY - JOUR
T1 - Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants
T2 - Natural course and associations in the first 4 months
AU - De Waal, C. G.
AU - Uijterschout, L.
AU - Abbink, M.
AU - Boersma, B.
AU - Vos, P.
AU - Rövekamp, W. W.
AU - Hudig, F.
AU - Akkermans, M. D.
AU - Van Goudoever, J. B.
AU - Brus, F.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Objective:To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.Study Design:ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.Results:ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).Conclusion:In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.
AB - Objective:To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.Study Design:ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.Results:ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).Conclusion:In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.
UR - http://www.scopus.com/inward/record.url?scp=85011841634&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/jp.2017.3
DO - https://doi.org/10.1038/jp.2017.3
M3 - Article
C2 - 28181998
SN - 0743-8346
VL - 37
SP - 690
EP - 694
JO - Journal of perinatology
JF - Journal of perinatology
IS - 6
ER -