CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain

  • Noemi Monti (Creator)
  • Rosaria A. Cavallaro (Creator)
  • Andrea Stoccoro (Creator)
  • Vincenzina Nicolia (Creator)
  • Sigfrido Scarpa (Creator)
  • Gabor G. Kovacs (Contributor)
  • Maria Teresa Fiorenza (Creator)
  • Marco Lucarelli (Creator)
  • Eleonora Aronica (Creator)
  • Isidre Ferrer (Contributor)
  • Fabio Coppedè (Creator)
  • Aron M. Troen (Creator)
  • Andrea Fuso (Creator)

Dataset

Description

The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the amyloid-β (Aβ) peptides, involved in Alzheimer’s Disease (AD). Other substrates of t...
Date made available2020
PublisherTaylor & Francis

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