Projects per year
Personal profile
Research interests
Keratinocyte cancer is the most frequent cancer in the Netherlands and worldwide, and its incidence is rapidly increasing. One of the main research lines in the Laboratory of experimental Dermatology (LED) studies the relation between the immune system and skin cancer (both melanoma and keratinocyte cancer (non-melanoma skin cancer (BCC, SCC). Due to its high mutational load, skin cancer is a immunogenic cancer, which (in part of the patients) can be effectively treated with immunotherapy. Understanding how the immune system interacts with skin cancer is crucial for improving current cancer immunotherapies. Currently we focus on how the tumor microenvironment affects tumor immunity (for example, if and how hypoxia controls PD-L1 expression in melanoma).
specialisation
Skin Cancer / Gene expression / Cancer Biology / Hypoxia / Immunology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Pigment team: Luiten R.M.: Immunology of melanoma and autoimmune skin diseases
Bakker, W., Post, N., van Uden, N., Chielie, S., Ouwerkerk, W., Luiten, R., Bekkenk, M., Wolkerstorfer, A., Tio, D., Rooker, A. & Holtappels, E.
1/02/2017 → …
Project: Research
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The Risk of Keratinocyte Cancer in Vitiligo and the Potential Mechanisms Involved
Rooker, A., Ouwerkerk, W., Bekkenk, M. W., Luiten, R. M. & Bakker, W. J., Feb 2024, In: Journal of Investigative Dermatology. 144, 2, p. 234-242 9 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
Immunity against Non-Melanoma Skin Cancer and the Effect of Immunosuppressive Medication on Non-Melanoma Skin Cancer Risk in Solid Organ Transplant Recipients
Bakker, D., Bakker, W. J., Bekkenk, M. W. & Luiten, R. M., 1 Oct 2023, In: Cells. 12, 20, 2441.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access1 Citation (Scopus) -
Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma
Willemsen, M., Tio, D., Krebbers, G., Kasiem, F. R., Jaspars, E. H., Matos, T. R., Bekkenk, M. W., Bakker, W. J. & Luiten, R. M., 1 Jun 2022, In: The American Journal of Dermatopathology. 44, 6, p. 416-423 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma
van Duijn, A., Willemsen, K. J., van Uden, N. O. P., Hoyng, L., Erades, S., Koster, J., Luiten, R. M. & Bakker, W. J., 2021, (E-pub ahead of print) In: Cancer Immunology, Immunotherapy.Research output: Contribution to journal › Article › Academic › peer-review
Open Access12 Citations (Scopus) -
IFN-γ-induced PD-L1 expression on human melanocytes is impaired in vitiligo
Willemsen, M., Krebbers, G., Tjin, E. P. M., Willemsen, K. J., Louis, A., Konijn, V. A. L., Narayan, V. S., Post, N. F., Bakker, W. J., Melief, C. J. M., Bekkenk, M. W. & Luiten, R. M., 2021, (E-pub ahead of print) In: Experimental dermatology.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus)