Dirkjan van Schaardenburg

(Principal Investigator), Prof. PhD

19992022

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Personal profile

Research interests

The focus of my research is on the development and course of rheumatoid arthritis. This development takes place over several years and involves inflammation of mucous membranes (mouth, lung, gut) leading to production of ant-citrullinated and other autoantibodies, after which the disease translocates to the joints. Early aggressive treatment appoaches have made a huge difference in maintaining joint integrity and function, and such appoaches are now tested in individuals at high risk for RA.

Recent data point to an overlap in risk factors for the development and outcome of both rheumatoid arthritis (RA) and cardiovascular diseases (CVD), as well as other chronic inflammatory diseases. In analogy to a successful life style intervention in CVD, a trial will start in Reade of a whole foods plant-based diet combined with exercise and stress management for patients with active RA, and also in patients with osteoarthritis and metabolic syndrome. A group of patients at risk for RA will receive the same intervention as a pilot study. If successful, analysis of MRI (liver, muscle) and gut microbiome will lead to a better understanding of the roles of microbiota and metabolism in the development of arthritis. 

Specialisation

Early and preclinical rheumatoid arthritis, life style medicine

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Network

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